Nature Medicine10, 355 - 361 (2004)
Published online: 31 March 2004; | doi:10.1038/nm1025
PPARs and the complex journey to obesity
Ronald M Evans1, Grant D Barish1, 2
& Yong-Xu Wang1
1
Ronald M. Evans, Grant D. Barish and Yong-Xu Wang are in the Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA; evans@salk.edu
2
G.D.B. is also in the Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco, San Francisco, California 94121, USA.
Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their intimate link. The three 'lipid-sensing' peroxisome proliferator−activated receptors (PPAR-, PPAR- and PPAR-) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.
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, PPAR-
and PPAR-
) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.
