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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Nature Immunology Nature Cell Biology Nature Genetics news@nature.com Nature Conferences Dissect Medicine NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Brief Communication Nature Medicine  10, 363 - 364 (2004) Published online: 29 February 2004; | doi:10.1038/nm1004 Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease Vicente E Torres1, Xiaofang Wang1, Qi Qian1, Stefan Somlo2, Peter C Harris1 & Vincent H Gattone II3 1  Division of Nephrology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. 2  Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06536, USA. 3  Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. Correspondence should be addressed to Vicente E Torres torres.vicente@mayo.eduAutosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. The vasopressin V2 receptor (VPV2R) antagonist OPC31260 has been effective in two animal models of PKD with pathologies that are probably related. Here we show, in a mouse model of ADPKD (Pkd2 -/tm1Som), a similar cellular phenotype and response to OPC31260 treatment, with reduction of renal cyclic AMP (cAMP) levels, prevention of renal enlargement, marked inhibition of cystogenesis and protection of renal function. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. NEWS AND VIEWS Another cystic mystery solved Nature Genetics News and Views (01 Mar 2002) RESEARCH Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist Nature Medicine Letter (01 Oct 2003) Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats Kidney International Original Article See all 74 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Open Innovation Challenges Single-cell Analysis Platform Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is... Direct Molecular Detection of Proteins and Nucleic Acids Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id... More Challenges Powered by: nature jobs Multiple Academic Positions in Psychology University of Toronto-Scarsborough Scarborough Ontario, Canada Endowed Professorship in Neuroscience University of Tennessee Health Science Center Memphis, Tennessee, USA More science jobs Post a job for free Competing financial interests Figures & Tables Supplementary info Export citation Search buyers guide:   ADVERTISEMENT

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