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Volume 10 Issue 2, February 2004

Physical barriers within tumor matrices can hinder deliverance of therapeutic agents to cancer cells, and make it difficult to measure macromolecule diffusion. In this month's Technical Report, Alexandrakis et al. (page 203) present a microscopy technique that reveals the intricate nature of barriers within tumors. The cover image shows GFP-marked glioblastoma cells (green) in the cranial window of a mouse visualized using two-photon fluorescence correlation microscopy. Tumor vessels are labeled with rhodamine-dextran (red), and collagen fibers are shown in purple. The image width is 250 µm.

Volume 10 Issue 2

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Editorial

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News

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Correspondence

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Book Review

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News & Views

  • Sepsis is by no means a single clinical entity; physicians must battle a variety of syndromes with only a vague notion of the molecular events that connect them. This vagueness now begins to dissipate with the identification of a molecule that can prevent the development of acute septic shock and severe sepsis (pages 161–167).

    • Haichao Wang
    • Christopher J Czura
    • Kevin J Tracey
    News & Views

  • Two studies find that adipocytes and macrophages have more in common than previously thought. The work bolsters the notion that the inflammatory response might link obesity to afflictions such as diabetes.

    • Michael Lehrke
    • Mitchell A Lazar
    News & Views

  • Sporadic breast cancers only rarely contain BRCA2 or BRCA1 mutations, despite the presence of such mutations in inherited breast and ovarian cancers. The identification of a new binding partner for BRCA-2 sheds light on this incongruity.

    • David M Livingston
    News & Views

  • Major countrywide and regional epidemics of dengue and dengue hemorrhagic fever occur in Southeast Asia every three to five years. A model examining the spread of epidemic dengue in Thailand helps explain why such patterns occur.

    • Duane J Gubler
    News & Views

  • Ceramide may mediate several causes of acute lung injury and provide the basis for new therapeutic approaches for this severe, hard-to-treat condition (pages 155–160).

    • Peter J Barnes
    News & Views
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Historical News and Views

  • The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion. The first fusion inhibitor has recently entered the clinic, and the hope is that more potent and broadly active compounds, based on molecular design, will follow.

    • Michael B Zwick
    • Erica O Saphire
    • Dennis R Burton
    Historical News and Views
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Historical Perspective

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Brief Communication

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Article

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Letter

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Technical Report

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Corrigendum

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On the Market

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Focus

  • A series of articles highlighting the major biomedical achievements of the past decade.

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