Nature Medicine
10, 1321 - 1328 (2004)
Published online: 21 November 2004; | doi:10.1038/nm1146
Small molecule RITA binds to p53, blocks p53−HDM-2 interaction and activates p53 function in tumorsNatalia Issaeva, Przemyslaw Bozko, Martin Enge, Marina Protopopova, Lisette G G C Verhoef, Maria Masucci, Aladdin Pramanik
& Galina SelivanovaSupplementary Fig. 1 (pdf 298K)
RITA did not induce p53 and did not suppress the growth of mouse cell lines in a p53-dependent manner. Supplementary Fig. 2 (pdf 961K)
Studies of RITA interaction with proteins using fluorescence correlation spectroscopy. Supplementary Fig. 3 (pdf 436K)
RITA did not inhibit the binding of p53 to the monoclonal antibody DO1 and Bcl-xL. Supplementary Table 1 (pdf 84K)
Growth suppression induced by RITA in different cell lines
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