Nature Medicine
10, 1366 - 1373 (2004)
Published online: 21 November 2004; | doi:10.1038/nm1140
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitisTian Wang, Terrence Town, Lena Alexopoulou, John F Anderson, Erol Fikrig
& Richard A FlavellSupplementary Fig. 1 (pdf 333K)
WNV infection in spleens from wild-type and Tlr3-/- mice. Supplementary Fig. 2 (pdf 131K)
Brain anatomical localization of WNV infection. Supplementary Fig. 3 (pdf 62K)
Conditioned media from WNV-infected wild-type, but not Tlr3-/- mouse microglia, induce neuronal apoptosis in vitro. Supplementary Fig. 4 (pdf 785K)
Blood-brain barrier permeability is increased after WNV infection in wild-type, but not Tlr3-/- or Tnf-r1-/- mice. Supplementary Table 1 (pdf 15K)
Summarized pathological observations of WNV-infected brains from wild-type or Tlr3-/- mice Supplementary Methods (pdf 10K)
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