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Letter
Nature Medicine 10, 1374–1378 (1 December 2004) | doi:10.1038/nm1133
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection
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Abstract
Innate immune responses provide the host with an early protection barrier against infectious agents, including viruses, and help shape the nature and quality of the subsequent adaptive immune responses of the host. Expression of ISG15 (UCRP), a ubiquitin-like protein, and protein ISGylation are highly increased upon viral infection.
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