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| A series of articles highlighting the major biomedical achievements of the past decade. |
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| Editorial | Top |
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Plus ça change, p1263
doi:10.1038/nm1204-1263
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(48K)
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| News | Top |
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Scientists turn anxious eyes to Bush's second term p1265
Jonathan Knight
doi:10.1038/nm1204-1265
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(148K)
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Scientists divided on relevance of race in medical research p1266
Damaris Christensen
doi:10.1038/nm1204-1266a
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(112K)
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UK criticized for embryo screening decision p1266
Xavier Bosch
doi:10.1038/nm1204-1266b
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(109K)
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New technologies deliver in treating neurological diseases p1267
Emily Singer
doi:10.1038/nm1204-1267a
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(127K)
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Despite snags and skepticism, Thai vaccine trial lumbers on p1267
T. V. Padma
doi:10.1038/nm1204-1267b
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(124K)
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Celebrating our 10th year
Immune response to SARS sets up puzzling paradox p1268
Apoorva Mandavilli
doi:10.1038/nm1204-1268a
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(126K)
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Celebrating our 10th year
HIV vaccine research a shot in the arm for immunologists p1268
Erika Check
doi:10.1038/nm1204-1268b
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(126K)
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News In Brief p1269
doi:10.1038/nm1204-1269
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(118K)
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Celebrating our 10th year
Profile: Philippa Marrack p1270
Kendall Powell
doi:10.1038/nm1204-1270
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(97K)
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Celebrating our 10th year
News Feature: The worm has turned pp1271 - 1272
Charlotte Schubert
doi:10.1038/nm1204-1271
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(294K)
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2004 Wrap Up pp1273 - 1277
doi:10.1038/nm1204-1273
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(582K)
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| Correspondence | Top |
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Correspondence 1: Cancer vaccines: pessimism in check pp1278 - 1279
Simone Mocellin, Susanna Mandruzzato, Vincenzo Bronte
& Francesco M Marincola
doi:10.1038/nm1204-1278
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(83K)
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Correspondence 2: Cancer vaccines: pessimism in check p1279
John M Timmerman
& Ronald Levy
doi:10.1038/nm1204-1279a
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(82K)
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Reply to "Cancer vaccines: pessimism in check" pp1279 - 1280
Steven A Rosenberg, James C Yang
& Nicholas P Restifo
doi:10.1038/nm1204-1279b
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(82K)
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| Commentaries | Top |
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Regional ethics organizations for protection of human research participants pp1283 - 1288
Anne Wood, Christine Grady
& Ezekiel J Emanuel
doi:10.1038/nm1204-1283
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(104K)
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Creating incentives for genomic research to improve targeting of therapies pp1289 - 1291
Barbara J Evans, David A Flockhart
& Eric M Meslin
doi:10.1038/nm1204-1289
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(82K)
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| Book Review | Top |
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Taking aim at Pharma pp1292 - 1293
Reviewed by: Ralph Snyderman
doi:10.1038/nm1204-1292
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(105K)
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| News and Views | Top |
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West Nile virus: crossing the blood-brain barrier pp1294 - 1295
Michael S Diamond
& Robyn S Klein
doi:10.1038/nm1204-1294
Abstract | Full text | PDF
(326K)
See also: Article by Wang et al. |
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Combination stroke therapy: easy as APC? pp1295 - 1296
Eng H Lo
doi:10.1038/nm1204-1295
Abstract | Full text | PDF
(284K)
See also: Letter by Liu et al. |
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Micromanaging insulin secretion pp1297 - 1298
Craig C Mello
& Michael P Czech
doi:10.1038/nm1204-1297
Abstract | Full text | PDF
(390K)
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Cancer drug discovery: the wisdom of imprecision pp1298 - 1299
Andrei V Gudkov
doi:10.1038/nm1204-1298
Abstract | Full text | PDF
(107K)
See also: Article by Issaeva et al. |
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Vitamin A helps gut T cells find their way in the dark pp1300 - 1301
Bengt Johansson-Lindbom
& William W Agace
doi:10.1038/nm1204-1300
Abstract | Full text | PDF
(368K)
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Chipping away at gallstones pp1301 - 1302
Kerry B Goralski
& Christopher J Sinal
doi:10.1038/nm1204-1301
Abstract | Full text | PDF
(417K)
See also: Article by Moschetta et al. |
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Research Highlights p1303
doi:10.1038/nm1204-1303
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(146K)
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Celebrating our 10th year
Antibody diversity: one enzyme to rule them all pp1304 - 1305
Michel C Nussenzweig
& Frederick W Alt
doi:10.1038/nm1204-1304
Abstract | Full text | PDF
(141K)
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Celebrating our 10th year
Historical Research Highlights p1306
doi:10.1038/nm1204-1306
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(107K)
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| Historical Perspective | Top |
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Celebrating our 10th year
An innately interesting decade of research in immunology pp1307 - 1320
Ronald N Germain
Published online: 03 December 2004 | doi:10.1038/nm1159
Abstract | Full text | PDF
(639K)
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| Articles | Top |
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Small molecule RITA binds to p53, blocks p53−HDM-2 interaction and activates p53 function in tumors pp1321 - 1328
Natalia Issaeva, Przemyslaw Bozko, Martin Enge, Marina Protopopova, Lisette G G C Verhoef, Maria Masucci, Aladdin Pramanik
& Galina Selivanova
Published online: 21 November 2004 | doi:10.1038/nm1146
Abstract | Full text | PDF
(692K)
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Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells pp1329 - 1335
Jose M Polo, Tania Dell'Oso, Stella Maris Ranuncolo, Leandro Cerchietti, David Beck, Gustavo F Da Silva, Gilbert G Prive, Jonathan D Licht
& Ari Melnick
Published online: 07 November 2004 | doi:10.1038/nm1134
Abstract | Full text | PDF
(1,454K)
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Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress pp1336 - 1343
Norbert Frey, Tomasa Barrientos, John M Shelton, Derk Frank, Hartmut Rütten, Doris Gehring, Christian Kuhn, Matthias Lutz, Beverly Rothermel, Rhonda Bassel-Duby, James A Richardson, Hugo A Katus, Joseph A Hill
& Eric N Olson
Published online: 14 November 2004 | doi:10.1038/nm1132
Abstract | Full text | PDF
(1,270K)
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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins pp1344 - 1351
Weijia Kong, Jing Wei, Parveen Abidi, Meihong Lin, Satoru Inaba, Cong Li, Yanling Wang, Zizheng Wang, Shuyi Si, Huaining Pan, Shukui Wang, Jingdan Wu, Yue Wang, Zhuorong Li, Jingwen Liu
& Jian-Dong Jiang
Published online: 07 November 2004 | doi:10.1038/nm1135
Abstract | Full text | PDF
(1,427K)
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Prevention of cholesterol gallstone disease by FXR agonists in a mouse model pp1352 - 1358
Antonio Moschetta, Angie L Bookout
& David J Mangelsdorf
Published online: 21 November 2004 | doi:10.1038/nm1138
Abstract | Full text | PDF
(628K)
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Therapeutic dendritic-cell vaccine for chronic HIV-1 infection pp1359 - 1365
Wei Lu, Luiz Claudio Arraes, Wylla Tatiana Ferreira
& Jean-Marie Andrieu
Published online: 28 November 2004 | doi:10.1038/nm1147
Abstract | Full text | PDF
(2,112K)
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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis pp1366 - 1373
Tian Wang, Terrence Town, Lena Alexopoulou, John F Anderson, Erol Fikrig
& Richard A Flavell
Published online: 21 November 2004 | doi:10.1038/nm1140
Abstract | Full text | PDF
(1,272K)
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| Letters | Top |
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Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection pp1374 - 1378
Kenneth J Ritchie, Chang S Hahn, Keun Il Kim, Ming Yan, Dabralee Rosario, Li Li, Juan Carlos de la Torre
& Dong-Er Zhang
Published online: 07 November 2004 | doi:10.1038/nm1133
Abstract | Full text | PDF
(705K)
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Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C pp1379 - 1383
Dong Liu, Tong Cheng, Huang Guo, José A Fernández, John H Griffin, Xiaomei Song
& Berislav V Zlokovic
Published online: 31 October 2004 | doi:10.1038/nm1122
Abstract | Full text | PDF
(408K)
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Adiponectin-mediated modulation of hypertrophic signals in the heart pp1384 - 1389
Rei Shibata, Noriyuki Ouchi, Masahiro Ito, Shinji Kihara, Ichiro Shiojima, David R Pimentel, Masahiro Kumada, Kaori Sato, Stephan Schiekofer, Koji Ohashi, Tohru Funahashi, Wilson S Colucci
& Kenneth Walsh
Published online: 21 November 2004 | doi:10.1038/nm1137
Abstract | Full text | PDF
(1,523K)
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| Technical Report | Top |
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Protein microarrays for multiplex analysis of signal transduction pathways pp1390 - 1396
Steven M Chan, Joerg Ermann, Leon Su, C Garrison Fathman
& Paul J Utz
Published online: 21 November 2004 | doi:10.1038/nm1139
Abstract | Full text | PDF
(1,011K)
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| Erratum | Top |
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Erratum: Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans p1397
H McShane, A A Pathan, C R Sander, S M Keating, S C Gilbert, K Huygen, H A Fletcher
& A V S Hill
doi:10.1038/nm1204-1397a
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(39K)
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| Corrigendum | Top |
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Corrigendum: Aberrant cannabinoid signaling impairs oviductal transport of embryos p1397
H Wang, Y Guo, D Wang, P J Kingsley, L J Marnett, S K Das, R N DuBois
& S K Dey
doi:10.1038/nm1204-1397b
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(39K)
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| New on the Market | Top |
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New on the market p1398
doi:10.1038/nm1204-1398
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(74K)
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