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Nature Medicine  10, 1379 - 1383 (2004)
Published online: 31 October 2004; | doi:10.1038/nm1122

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C

Dong Liu, Tong Cheng, Huang Guo, José A Fernández, John H Griffin, Xiaomei Song & Berislav V Zlokovic
 
Figure 1 thumbnailFigure 1.
tPA toxicity to human BEC and cytoprotection by human APC.

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 Figure 2 thumbnailFigure 2.
tPA's apoptotic signal in hypoxic human BEC requires caspase-8 and is blocked by APC.

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Figure 3 thumbnailFigure 3.
tPA shifts NMDA-induced apoptosis in mouse cortical neurons to caspase-8 which is blocked by mouse APC.

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 Figure 4 thumbnailFigure 4.
tPA-induced cerebral injury in a mouse stroke model and protection by mouse APC.

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