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Letter
Nature Medicine  10, 1251 - 1256 (2004)
Published online: 24 October 2004; | doi:10.1038/nm1125

The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

Kwai Wa Cheng, John P Lahad, Wen-lin Kuo, Anna Lapuk, Kyosuke Yamada, Nelly Auersperg, Jinsong Liu, Karen Smith-McCune, Karen H Lu, David Fishman, Joe W Gray & Gordon B Mills

Supplementary Fig. 1 (pdf 17K)
RAB25 gene expression is associated with decreased overall survival in stage I−IV serous epithelial ovarian cancer patients.

Supplementary Fig. 2 (pdf 18K)
RAB25 gene expression is associated with decreased disease free period in breast cancer patients, using data acquired from the Stanford breast cancer data set19.

Supplementary Fig. 3 (pdf 30K)
Effect of RAB25 stable expression on cell proliferation in 1% or 10% fetal bovine serum containing media.

Supplementary Fig. 4 (pdf 162K)
Knock down of RAB25 mRNA expression by RNA interference (RNAi) decreases cell number in A2780, OVCAR3, MCF-7 and in RAB25 stable transfected A2780 cells.


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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