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| A series of articles highlighting the major biomedical achievements of the past decade. |
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| Editorial | Top |
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Withdrawal syndrome p1143
doi:10.1038/nm1104-1143
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(43K)
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| News | Top |
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Celebrating our 10th year
Scientists seeking HIV in all the wrong places p1145
Helen Pearson
doi:10.1038/nm1104-1145a
Abstract | Full text | PDF
(380K)
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Spain breaks financial pact with pharmaceutical industry p1145
Xavier Bosch
doi:10.1038/nm1104-1145b
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(380K)
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Scientists stumped by test that promises tailored treatment p1146
Alla Katsnelson
doi:10.1038/nm1104-1146a
Abstract | Full text | PDF
(268K)
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Database draws attention to not-so-Nobel intentions p1146
Peter Vermij
doi:10.1038/nm1104-1146b
Abstract | Full text | PDF
(268K)
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Israeli researchers eye simple test for multiple sclerosis p1147
Tania Hershman
doi:10.1038/nm1104-1147a
Abstract | Full text | PDF
(232K)
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Reports of SIDS-virus link greatly exaggerated, experts say p1147
Douglas Sipp
doi:10.1038/nm1104-1147b
Abstract | Full text | PDF
(232K)
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Celebrating our 10th year
Chiron flu flap suggests vaccine industry needs shot in the arm p1148
Emily Singer
doi:10.1038/nm1104-1148a
Abstract | Full text | PDF
(169K)
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Celebrating our 10th year
Genetics may aggravate India's growing AIDS problem p1148
K.S. Jayaraman
doi:10.1038/nm1104-1148b
Abstract | Full text | PDF
(169K)
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News In Brief p1149
doi:10.1038/nm1104-1149
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(150K)
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Celebrating our 10th year
Profile: David Ho p1150
Apoorva Mandavilli
doi:10.1038/nm1104-1150
Abstract | Full text | PDF
(129K)
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Celebrating our 10th year
News Feature: Eye in the sky pp1151 - 1152
Alan Dove
doi:10.1038/nm1104-1151
Abstract | Full text | PDF
(779K)
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| Correspondence | Top |
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Translation of cancer immunotherapies p1153
James J. Mulé
& Jeffrey S. Weber
doi:10.1038/nm1104-1153a
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(68K)
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Translation of cancer immunotherapies pp1153 - 1154
Drew Pardoll
& James Allison
doi:10.1038/nm1104-1153b
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(79K)
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Translation of cancer immunotherapies pp1154 - 1155
Jonathan Skipper, Eric W Hoffman, Jill O'Donnell-Tormey
& Lloyd J Old
doi:10.1038/nm1104-1154
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(84K)
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Translation of cancer immunotherapies p1155
Drew Pardoll
& James Allison
doi:10.1038/nm1104-1155a
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(85K)
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Active tissue factor in blood? pp1155 - 1156
Saulius Butenas
& Kenneth G Mann
doi:10.1038/nm1104-1155b
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(85K)
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Active tissue factor in blood? p1156
Vladimir Y. Bogdanov, James Hathcock
& Yale Nemerson
doi:10.1038/nm1104-1156
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(75K)
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New paradigms, animal models may lift antidepressant research p1157
David W. Schulz
doi:10.1038/nm1104-1157
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(59K)
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| Book Review | Top |
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The 'German synthetics' p1159
Reviewed by: Lawrence Robbins
doi:10.1038/nm1104-1159
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(171K)
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| News and Views | Top |
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Can nicotine treat sepsis? pp1161 - 1162
Michael A Matthay
& Lorraine B Ware
doi:10.1038/nm1104-1161
Abstract | Full text | PDF
(741K)
See also: Article by Wang et al. |
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Hypertension with a grain of salt pp1163 - 1164
Ursula Danilczyk
& Josef Penninger
doi:10.1038/nm1104-1163
Abstract | Full text | PDF
(829K)
See also: Article by Iwamoto et al. |
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H. pylori's inside job p1164
Charlotte Schubert
doi:10.1038/nm1104-1164
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(394K)
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Transplantation tolerance: babies take the first step pp1165 - 1166
Jagdeep S Obhrai
& Fadi G Lakkis
doi:10.1038/nm1104-1165
Abstract | Full text | PDF
(384K)
See also: Article by Fan et al. |
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Stem cells bank on ATM machine pp1166 - 1168
Anthony D Whetton
doi:10.1038/nm1104-1166
Abstract | Full text | PDF
(281K)
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Turning up the heat in the fat cell pp1168 - 1169
Domenico Accili
& Luca Valenti
doi:10.1038/nm1104-1168
Abstract | Full text | PDF
(132K)
See also: Article by Komazawa et al. |
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Transporter of a malaria catastrophe pp1169 - 1171
Thomas E Wellems
doi:10.1038/nm1104-1169
Abstract | Full text | PDF
(489K)
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Research highlights p1172
doi:10.1038/nm1104-1172
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(150K)
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Celebrating our 10th year
From plankton to pathogen recognition pp1173 - 1174
Robert L Modlin
& Genhong Cheng
doi:10.1038/nm1104-1173
Abstract | Full text | PDF
(501K)
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Celebrating our 10th year
Historical Research Highlights p1175
doi:10.1038/nm1104-1175
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(168K)
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| Historical Perspective | Top |
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Celebrating our 10th year
From Pasteur to genomics: progress and challenges in infectious diseases pp1177 - 1185
Rino Rappuoli
Published online: 29 October 2004 | doi:10.1038/nm1129
Abstract | Full text | PDF
(707K)
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| Brief Communications | Top |
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Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells pp1187 - 1189
Andrzej Ptasznik, Yuji Nakata, Anna Kalota, Stephen G Emerson
& Alan M. Gewirtz
Published online: 24 October 2004 | doi:10.1038/nm1127
Abstract | Full text | PDF
(1,378K)
| Supplementary Information |
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Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation pp1190 - 1192
Irene H Cheng, Jorge J Palop, Luke A Esposito, Nga Bien-Ly, Fengrong Yan
& Lennart Mucke
Published online: 24 October 2004 | doi:10.1038/nm1123
Abstract | Full text | PDF
(1,232K)
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| Articles | Top |
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Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle pp1193 - 1199
Takahiro Iwamoto, Satomi Kita, Jin Zhang, Mordecai P Blaustein, Yuji Arai, Shigeru Yoshida, Koji Wakimoto, Issei Komuro
& Takeshi Katsuragi
Published online: 10 October 2004 | doi:10.1038/nm1118
Abstract | Full text | PDF
(1,306K)
| Supplementary Information
See also: News and Views by Danilczyk & Penninger |
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S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide pp1200 - 1207
Takeshi Adachi, Robert M Weisbrod, David R Pimentel, Jia Ying, Victor S Sharov, Christian Schöneich
& Richard A Cohen
Published online: 17 October 2004 | doi:10.1038/nm1119
Abstract | Full text | PDF
(2,281K)
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Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice pp1208 - 1215
Nobuyasu Komazawa, Morihiro Matsuda, Gen Kondoh, Wataru Mizunoya, Masanori Iwaki, Toshiyuki Takagi, Yasuyuki Sumikawa, Kazuo Inoue, Akira Suzuki, Tak Wah Mak, Toru Nakano, Tohru Fushiki, Junji Takeda
& Iichiro Shimomura
Published online: 17 October 2004 | doi:10.1038/nm1117
Abstract | Full text | PDF
(1,393K)
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Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis pp1216 - 1221
Hong Wang, Hong Liao, Mahendar Ochani, Marilou Justiniani, Xinchun Lin, Lihong Yang, Yousef Al-Abed, Haichao Wang, Christine Metz, Edmund J Miller, Kevin J Tracey
& Luis Ulloa
Published online: 24 October 2004 | doi:10.1038/nm1124
Abstract | Full text | PDF
(1,156K)
| Supplementary Information
See also: News and Views by Matthay & Ware |
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Heparin prevents antiphospholipid antibody−induced fetal loss by inhibiting complement activation pp1222 - 1226
Guillermina Girardi, Patricia Redecha
& Jane E Salmon
Published online: 17 October 2004 | doi:10.1038/nm1121
Abstract | Full text | PDF
(564K)
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Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation pp1227 - 1233
Xiaohu Fan, Andrew Ang, Stacey M Pollock-BarZiv, Anne I Dipchand, Phillip Ruiz, Gregory Wilson, Jeffrey L Platt
& Lori J West
Published online: 24 October 2004 | doi:10.1038/nm1126
Abstract | Full text | PDF
(1,973K)
| Supplementary Information
See also: News and Views by Obhrai & Lakkis |
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| Letters | Top |
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TCR affinity and negative regulation limit autoimmunity pp1234 - 1239
Matthew A Gronski, Jonathan M Boulter, Demetrius Moskophidis, Linh T Nguyen, Kaisa Holmberg, Alisha R Elford, Elissa K Deenick, Hee O Kim, Josef M Penninger, Bernhard Odermatt, Awen Gallimore, Nicholas R J Gascoigne
& Pamela S Ohashi
Published online: 03 October 2004 | doi:10.1038/nm1114
Abstract | Full text | PDF
(569K)
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Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans pp1240 - 1244
Helen McShane, Ansar A Pathan, Clare R Sander, Sheila M Keating, Sarah C Gilbert, Kris Huygen, Helen A Fletcher
& Adrian V S Hill
Published online: 24 October 2004 | doi:10.1038/nm1128
Abstract | Full text | PDF
(111K)
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Cardiomyocyte-restricted peroxisome proliferator-activated receptor- deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy pp1245 - 1250
Lihong Cheng, Guoliang Ding, Qianhong Qin, Yao Huang, William Lewis, Nu He, Ronald M Evans, Michael D Schneider, Florence A Brako, Yan Xiao, Yuqing E Chen
& Qinglin Yang
Published online: 10 October 2004 | doi:10.1038/nm1116
Abstract | Full text | PDF
(2,305K)
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The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers pp1251 - 1256
Kwai Wa Cheng, John P Lahad, Wen-lin Kuo, Anna Lapuk, Kyosuke Yamada, Nelly Auersperg, Jinsong Liu, Karen Smith-McCune, Karen H Lu, David Fishman, Joe W Gray
& Gordon B Mills
Published online: 24 October 2004 | doi:10.1038/nm1125
Abstract | Full text | PDF
(1,933K)
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| Technical Report | Top |
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Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model pp1257 - 1260
Lene Uhrbom, Edward Nerio
& Eric C Holland
Published online: 24 October 2004 | doi:10.1038/nm1120
Abstract | Full text | PDF
(956K)
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| Corrigendum | Top |
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Corrigendum: 4-1BB-mediated immunotherapy of rheumatoid arthritis p1261
Su K Seo, Jae H Choi, Young H Kim, Woo J Kang, Hye Y Park, Jae H Suh, Beom K Choi, Dass S Vinay
& Byoung S Kwon
doi:10.1038/nm1104-1261
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(35K)
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| New on the Market | Top |
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New on the market p1262
doi:10.1038/nm1104-1262
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(202K)
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