Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 10, 1168 - 1169 (2004)
doi:10.1038/nm1104-1168
There is a Retraction (June 2005) associated with this News and Views.
Turning up the heat in the fat cell
Domenico Accili1 & Luca Valenti1
- Domenico Accili and Luca Valenti are in the Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA. e-mail: da230@columbia.edu
Abstract
Obesity researchers have inched closer to a long-sought goal: creating a fat cell that burns up calories without causing obesity. The trick is to knock out a protein better known for its role in cancer, the inositol-phosphatase Pten (pages 1208–1215).
The growing incidence of obesity and diabetes has renewed interest in studies of adipocyte physiology. At the same time, the advent of techniques of gene recombination in vivo has made possible an unprecedented level of detail in the analysis of the contribution of different signaling pathways to various fat cell functions.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
