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Nature Medicine 10, 1166 - 1168 (2004)
doi:10.1038/nm1104-1166
Stem cells bank on ATM machine
Anthony D Whetton1
- Anthony D. Whetton is a member of the Faculty of Medical and Human Sciences and the Mass Spectrometry Laboratory, Paterson Institute for Cancer Research, Christie Hospital, University of Manchester, Manchester M20 9BX, UK. e-mail: tony.whetton@manchester.ac.uk
Abstract
Hematopoietic stem cells maintain the capacity for self-renewal despite the hazard of oxidative damage. Studies in mice show that this hazard is held in check by the ataxia telangiectasia mutated gene, operating through some well-known tumor suppressors.
Recessive mutations in the ATM gene cause ataxia telangiectasia, characterized by neurodegeneration, premature aging, cancer predisposition and immune defects1, 2. ATM is a cell-cycle checkpoint regulator activated by DNA double-strand breaks2.
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