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Nature Medicine 10, 1165 - 1166 (2004)
doi:10.1038/nm1104-1165
Transplantation tolerance: babies take the first step
Jagdeep S Obhrai1 & Fadi G Lakkis1
- The authors are in the Section of Nephrology (Department of Internal Medicine) and the Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06511, USA. e-mail: fadi.lakkis@yale.edu or e-mail: jagdeep.obhrai@yale.edu
Abstract
Babies will accept transplants from donors of different blood groups, a situation that is catastrophic in adults. The basis for this acceptance is now examined and found to hinge on B-cell tolerance (pages 1227–1233).
Transplantation immunobiology for the past half century has been shaped by the pursuit of tolerance—acceptance of a foreign graft as self while maintaining responsiveness to other antigens. In 1953, Billingham, Brent and Medawar conceptualized transplantation tolerance and proved it is possible in laboratory animals1.
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RESEARCH
Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantationNature Medicine Article (01 Nov 2004)
