Thomas E Wellems is in the Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-8132, USA. tew@helix.nih.gov
Amantadine, a proton-channel blocker used to treat influenza, also inhibits growth of the malaria parasite Plasmodium falciparum. The drug is most active against parasite strains resistant to the increasingly ineffective drug chloroquine. The molecular basis of this enhanced activity is now examined, opening the door to new ways to attack chloroquine resistance.
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