Anthony D. Whetton is a member of the Faculty of Medical and Human Sciences and the Mass Spectrometry Laboratory, Paterson Institute for Cancer Research, Christie Hospital, University of Manchester, Manchester M20 9BX, UK. tony.whetton@manchester.ac.uk
Hematopoietic stem cells maintain the capacity for self-renewal despite the hazard of oxidative damage. Studies in mice show that this hazard is held in check by the ataxia telangiectasia mutated gene, operating through some well-known tumor suppressors.
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