Nature Medicine
10, 1067 - 1073 (2004)
Published online: 26 September 2004; | doi:10.1038/nm1106
Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathwayReiko Hanada, Hitoshi Teranishi, James Todd Pearson, Mamoru Kurokawa, Hiroshi Hosoda, Nobuhiro Fukushima, Yoshihiko Fukue, Ryota Serino, Hiroaki Fujihara, Yoichi Ueta, Masahito Ikawa, Masaru Okabe, Noboru Murakami, Mikiyasu Shirai, Hironobu Yoshimatsu, Kenji Kangawa
& Masayasu KojimaSupplementary Fig. 1 (pdf 99K)
Generation of NMU-/- mice. Supplementary Fig. 2 (pdf 37K)
Plasma levels of glucose, insulin, leptin, lipids, corticosterone and assessment of thyroid function in NMU-/- and WT mice after a 16-hr starvation period (n = 16). Supplementary Fig. 3 (pdf 56K)
Circadian phenotypes of feeding behavior in NMU-/- mice and WT mouse. Supplementary Fig. 4 (pdf 31K)
Suppression of food intake by bolus ICV administration of NMU (3 nmol/mouse or 5nmol/rat) in animals without leptin signaling after fasting (n = 6 per group).
|
