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| A series of articles highlighting the major biomedical achievements of the past decade. |
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| Editorial | Top |
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Roadblocks to cancer cures p1003
doi:10.1038/nm1004-1003
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(51K)
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| News | Top |
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Therapeutic cloning gives silenced genes a second voice p1005
Kris Novak
doi:10.1038/nm1004-1005a
Abstract | Full text | PDF
(275K)
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US panel recommends 'black box' warnings for antidepressants p1005
Erika Check
doi:10.1038/nm1004-1005b
Abstract | Full text | PDF
(275K)
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Scientists stumped by dual push for open access, secrecy p1006
Emily Singer
doi:10.1038/nm1004-1006a
Abstract | Full text | PDF
(350K)
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Europe's retired research chimps stranded p1006
Xavier Bosch
doi:10.1038/nm1004-1006b
Abstract | Full text | PDF
(350K)
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Celebrating our 10th year
Ethical quagmire awaits vaccine for cocaine addiction p1007
Alla Katsnelson
doi:10.1038/nm1004-1007a
Abstract | Full text | PDF
(137K)
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Celebrating our 10th year
Inflamed brains can trigger the blues, studies suggest p1007
Gunjan Sinha
doi:10.1038/nm1004-1007b
Abstract | Full text | PDF
(137K)
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News In Brief p1008
doi:10.1038/nm1004-1008
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(259K)
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Profile: John Hardy p1009
Bruce Diamond
doi:10.1038/nm1004-1009
Abstract | Full text | PDF
(132K)
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News Feature: Mood Swings pp1010 - 1012
Apoorva Mandavilli
doi:10.1038/nm1004-1010
Abstract | Full text | PDF
(1,385K)
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| Correspondence | Top |
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Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo pp1013 - 1014
Changhui Mao, Dezheng Dong, Edward Little, Shengzhan Luo
& Amy S Lee
doi:10.1038/nm1004-1013
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(696K)
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Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo p1014
Takao Iwawaki, Kenji Kohno
& Masayuki Miura
doi:10.1038/nm1004-1014
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(514K)
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| Commentaries | Top |
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2004 Albert Lasker Medical Research Awards
Foreword: Towering science: an ounce of creativity is worth a ton of impact pp1015 - 1017
Joseph L Goldstein
doi:10.1038/nm1004-1015
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(413K)
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2004 Albert Lasker Medical Research Awards
From chemical warfare to breast cancer management pp1018 - 1021
Elwood V Jensen
doi:10.1038/nm1004-1018
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(1,119K)
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2004 Albert Lasker Medical Research Awards
A transcriptional basis for physiology pp1022 - 1026
Ronald Evans
doi:10.1038/nm1004-1022
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(612K)
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2004 Albert Lasker Medical Research Awards
How I became one of the fathers of a superfamily pp1027 - 1031
Pierre Chambon
doi:10.1038/nm1004-1027
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(283K)
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2004 Albert Lasker Medical Research Awards
How a jolt and a bolt in a dentist's chair revolutionized cataract surgery pp1032 - 1033
Joseph L Goldstein
doi:10.1038/nm1004-1032
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(302K)
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2004 Albert Lasker Medical Research Awards
Explorations in the land of DNA and beyond pp1034 - 1037
Matthew Meselson
doi:10.1038/nm1004-1034
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(1,636K)
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| Book Reviews | Top |
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The 'neurocentric circle' p1039
Reviewed by: Marco Piccolino
doi:10.1038/nm1004-1039
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(172K)
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Biography of a cytologist p1040
Reviewed by: Brian Charlesworth
doi:10.1038/nm1004-1040
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(145K)
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| News and Views | Top |
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VEGF obstructs the lungs pp1041 - 1042
Marc E Rothenberg
doi:10.1038/nm1004-1041
Abstract | Full text | PDF
(698K)
See also: Article by Lee et al. |
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Hematopoietic stem cells get closer to the bone pp1042 - 1044
Connie Eaves
doi:10.1038/nm1004-1042
Abstract | Full text | PDF
(733K)
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Bone marrow spawns brain killers pp1044 - 1045
Costantino Iadecola
doi:10.1038/nm1004-1044
Abstract | Full text | PDF
(441K)
See also: Article by Yu et al. |
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Memory may not need reminding pp1045 - 1047
Robert A Seder
& David L Sacks
doi:10.1038/nm1004-1045
Abstract | Full text | PDF
(253K)
See also: Article by Zaph et al. |
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Suppressing the self in rheumatoid arthritis pp1047 - 1049
Robert S Mittler
doi:10.1038/nm1004-1047
Abstract | Full text | PDF
(342K)
See also: Article by Seo et al. |
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Nutrient sensor links obesity with diabetes risk pp1049 - 1050
Mary-Elizabeth Patti
& Barbara B Kahn
doi:10.1038/nm1004-1049
Abstract | Full text | PDF
(143K)
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Research Highlights p1051
doi:10.1038/nm1004-1051
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(245K)
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Celebrating our 10th year
Easing the brakes on spinal cord repair pp1052 - 1053
Lisa McKerracher
& Samuel David
doi:10.1038/nm1004-1052
Abstract | Full text | PDF
(467K)
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Celebrating our 10th year
Historical Research Highlights p1054
doi:10.1038/nm1004-1054
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(408K)
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| Historical Perspective | Top |
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Celebrating our 10th year
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs pp1055 - 1063
Mark S Forman, John Q Trojanowski
& Virginia M-Y Lee
Published online: 30 September 2004 | doi:10.1038/nm1113
Abstract | Full text | PDF
(3,070K)
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| Brief Communication | Top |
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Nonsteroidal anti-inflammatory drugs lower A 42 and change presenilin 1 conformation pp1065 - 1066
Alberto Lleó, Oksana Berezovska, Lauren Herl, Susan Raju, Amy Deng, Brian J Bacskai, Matthew P Frosch, Michael Irizarry
& Bradley T Hyman
Published online: 26 September 2004 | doi:10.1038/nm1112
Abstract | Full text | PDF
(514K)
| Supplementary Information |
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| Articles | Top |
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Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway pp1067 - 1073
Reiko Hanada, Hitoshi Teranishi, James Todd Pearson, Mamoru Kurokawa, Hiroshi Hosoda, Nobuhiro Fukushima, Yoshihiko Fukue, Ryota Serino, Hiroaki Fujihara, Yoichi Ueta, Masahito Ikawa, Masaru Okabe, Noboru Murakami, Mikiyasu Shirai, Hironobu Yoshimatsu, Kenji Kangawa
& Masayasu Kojima
Published online: 26 September 2004 | doi:10.1038/nm1106
Abstract | Full text | PDF
(1,165K)
| Supplementary Information |
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Aberrant cannabinoid signaling impairs oviductal transport of embryos pp1074 - 1080
Haibin Wang, Yong Guo, Dingzhi Wang, Philip J Kingsley, Lawrence J Marnett, Sanjoy K Das, Raymond N DuBois
& Sudhansu K Dey
Published online: 19 September 2004 | doi:10.1038/nm1104
Abstract | Full text | PDF
(894K)
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Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury pp1081 - 1087
Liqun Yu, Zhihong Huang, Juliana Mariani, Yumei Wang, Michael Moskowitz
& Jiang-Fan Chen
Published online: 26 September 2004 | doi:10.1038/nm1103
Abstract | Full text | PDF
(424K)
| Supplementary Information
See also: News and Views by Iadecola |
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4-1BB-mediated immunotherapy of rheumatoid arthritis pp1088 - 1094
Su K Seo, Jae H Choi, Young H Kim, Woo J Kang, Hye Y Park, Jae H Suh, Beom K Choi, Dass S Vinay
& Byoung S Kwon
Published online: 26 September 2004 | doi:10.1038/nm1107
Abstract | Full text | PDF
(2,670K)
| Supplementary Information
See also: News and Views by Mittler |
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Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung pp1095 - 1103
Chun Geun Lee, Holger Link, Peter Baluk, Robert J Homer, Svetlana Chapoval, Vineet Bhandari, Min Jong Kang, Lauren Cohn, Yoon Keun Kim, Donald M McDonald
& Jack A Elias
Published online: 19 September 2004 | doi:10.1038/nm1105
Abstract | Full text | PDF
(3,585K)
| Supplementary Information
See also: News and Views by Rothenberg |
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Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites pp1104 - 1110
Colby Zaph, Jude Uzonna, Stephen M Beverley
& Phillip Scott
Published online: 26 September 2004 | doi:10.1038/nm1108
Abstract | Full text | PDF
(2,268K)
| Supplementary Information
See also: News and Views by Seder & Sacks |
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Modeling the emergence of the 'hot zones': tuberculosis and the amplification dynamics of drug resistance pp1111 - 1116
Sally M Blower
& Tom Chou
Published online: 19 September 2004 | doi:10.1038/nm1102
Abstract | Full text | PDF
(663K)
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| Letters | Top |
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Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness pp1117 - 1121
Ted Cohen
& Megan Murray
Published online: 19 September 2004 | doi:10.1038/nm1110
Abstract | Full text | PDF
(148K)
| Supplementary Information |
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Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator pp1122 - 1127
Christian J Hunter, André Dejam, Arlin B Blood, Howard Shields, Daniel B Kim-Shapiro, Roberto F Machado, Selamawit Tarekegn, Neda Mulla, Andrew O Hopper, Alan N Schechter, Gordon G Power
& Mark T Gladwin
Published online: 12 September 2004 | doi:10.1038/nm1109
Abstract | Full text | PDF
(285K)
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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide pp1128 - 1132
Hideaki Kaneto, Yoshihisa Nakatani, Takeshi Miyatsuka, Dan Kawamori, Taka-aki Matsuoka, Munehide Matsuhisa, Yoshitaka Kajimoto, Hidenori Ichijo, Yoshimitsu Yamasaki
& Masatsugu Hori
Published online: 26 September 2004 | doi:10.1038/nm1111
Abstract | Full text | PDF
(1,244K)
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| Technical Report | Top |
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Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis pp1133 - 1138
Fabian Kiessling, Susanne Greschus, Matthias P Lichy, Michael Bock, Christian Fink, Silvia Vosseler, Jens Moll, Margareta M Mueller, Norbert E. Fusenig, Horst Traupe
& Wolfhard Semmler
Published online: 07 September 2004 | doi:10.1038/nm1101
Abstract | Full text | PDF
(822K)
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| Erratum | Top |
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Erratum: CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation p1139
Jill R Crittenden, Wolfgang Bergmeier, Yanyu Zhang, Crystal L Piffath, Yuqiong Liang, Denisa D Wagner, David E Housman
& Ann M Graybiel
doi:10.1038/nm1004-1139a
Full text | PDF
(43K)
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| Corrigendum | Top |
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Corrigendum: CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer p1139
Zhongmin Guo, Jürgen F Linn, Guojun Wu, Sarah L Anzick, Claus F Eisenberger, Sarel Halachmi, Yoram Cohen, Alexey Fomenkov, Mohammad O Hoque, Kenji Okami, Gabriel Steiner, James M Engles, Motonabu Osada, Chulso Moon, Edward Ratovitski, Jeffrey M Trent, Paul S Meltzer, William H Westra, Lambertus A Kiemeney, Mark P Schoenberg, David Sidransky
& Barry Trink
doi:10.1038/nm1004-1139b
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(43K)
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| New on the Market | Top |
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New on the market p1141
doi:10.1038/nm1004-1141
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(197K)
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