Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 10, 1045 - 1047 (2004)
doi:10.1038/nm1004-1045
Memory may not need reminding
Robert A Seder1 & David L Sacks2
- Robert A. Seder is in the Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. e-mail: rseder@mail.nih.gov
- David L. Sacks is at the Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA.
Abstract
After primary Leishmania major infection, two populations of CD4+ T cells, termed 'effector' and 'central memory' T cells, are generated. Work in mice shows that both populations can mediate protection against subsequent infection, and that persistent infection keeps the effector response robust (pages 1104–1110).
The fundamental basis of vaccination is the generation and maintenance of antigen-specific immune responses sufficient to mediate protection upon infectious challenge. The most effective vaccines provide protection years after their administration.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasitesNature Medicine Article (01 Oct 2004)
Distinct lineages of T H 1 cells have differential capacities for memory cell generation in vivoNature Immunology Article (01 Sep 2002)
Multifunctional T H 1 cells define a correlate of vaccine-mediated protection against Leishmania majorNature Medicine Article (01 Jul 2007)
See all 5 matches for Research