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Nature Medicine 10, 1044 - 1045 (2004)
doi:10.1038/nm1004-1044
Bone marrow spawns brain killers
Costantino Iadecola1
- Costantino Iadecola is in the Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical Center of Cornell University, New York, New York 10021, USA. e-mail: coi2001@med.cornell.edu
Abstract
The reduction in blood flow to the brain that causes a stroke triggers a deadly cascade of events that can lead to brain death. Studies in mice show that activation of an adenosine receptor on neutrophils invading the brain from the blood contribute to the damage (pages 1081–1087).
Ischemic stroke is a devastating brain disease that afflicts millions worldwide1. It is caused by a sudden occlusion of a cerebral artery that cuts off the blood supply to a restricted region of the brain.
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