Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 10, 1044 - 1045 (2004)
doi:10.1038/nm1004-1044
Bone marrow spawns brain killers
Costantino Iadecola1
- Costantino Iadecola is in the Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical Center of Cornell University, New York, New York 10021, USA. e-mail: coi2001@med.cornell.edu
Abstract
The reduction in blood flow to the brain that causes a stroke triggers a deadly cascade of events that can lead to brain death. Studies in mice show that activation of an adenosine receptor on neutrophils invading the brain from the blood contribute to the damage (pages 1081–1087).
Ischemic stroke is a devastating brain disease that afflicts millions worldwide1. It is caused by a sudden occlusion of a cerebral artery that cuts off the blood supply to a restricted region of the brain.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brainJournal of Cerebral Blood Flow & Metabolism Original Article
Selective inactivation or reconstitution of adenosine A 2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injuryNature Medicine Article (01 Oct 2004)
Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injuryJournal of Cerebral Blood Flow & Metabolism Original Article
Inducible nitric oxide synthase contributes to gender differences in ischemic brain injuryJournal of Cerebral Blood Flow & Metabolism Original Article
