1
Robert A. Seder is in the Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. rseder@mail.nih.gov
2
David L. Sacks is at the Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA.
After primary Leishmania major infection, two populations of CD4+ T cells, termed 'effector' and 'central memory' T cells, are generated. Work in mice shows that both populations can mediate protection against subsequent infection, and that persistent infection keeps the effector response robust (pages 1104−1110).
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