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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Nature Immunology Nature Cell Biology Nature Genetics news@nature.com Nature Conferences Dissect Medicine NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Nature Medicine  10, 26 - 27 (2004) doi:10.1038/nm0104-26 Androgen receptor outwits prostate cancer drugs John T Isaacs1 & William B Isaacs2 1  John T. Isaacs is at The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA. 2  William B. Isaacs is in the Department of Urology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA. wisaacs@jhmi.edu Almost all prostate cancer patients become resistant to therapy that blocks androgen-mediated cell proliferation. The key to this resistance may lie in expression of the androgen receptor itself (pages 33−39). MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. RESEARCH A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase Nature Medicine Article (01 Mar 1999) Molecular determinants of resistance to antiandrogen therapy Nature Medicine Article (01 Jan 2004) The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry Asian Journal of Andrology Original Article Octreotide scintigraphy and Chromogranin A do not predict clinical response in patients with octreotide acetate-treated hormone-refractory prostate cancer Prostate Cancer and Prostatic Diseases Original Article See all 7 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Open Innovation Challenges Optimizing Sub-cellular Localization Tags Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... Novel Approaches to Protecting Maize from Insect Damage Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... More Challenges Powered by: nature jobs Scientist / Sr. Scientist - Biopharmaceutics Syngene International Bangalore, Karnataka 560099 India Tenure-Track Faculty Position Experimental Condensed Matter Physics Department of Physics McGill University McGill Univerisity Montreal, Quebec, Canada More science jobs Post a job for free Figures & Tables See also: Article by Chen et al. Export citation Search buyers guide:   ADVERTISEMENT

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