Kinichi Nakashima, Sophia Colamarino
& Fred H Gage
Kinichi Nakashima, Sophia Colamarino and Fred H. Gage are in the Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA; K.N. is also in the Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811, Japan. nakashima@salk.edu or gage@salk.edu
A new drug that activates the Wnt pathway maintains the undifferentiated state of pluripotent human and mouse embryonic stem cells. This finding opens the door to defining the precise molecular mechanism of embryonic stem cell self-renewal, which is crucial for providing a steady supply of embryonic stem cells for regenerative medicine (pages 55−63).
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