Hugh Auchincloss is in the Transplant Unit, Surgical Services, Massachusetts General Hospital and Brigham and Women's Hospital, WAC 478, 15 Parkman Street, Boston, Massachusetts 02114-3117, USA. auchincloss@helix.mgh.harvard.edu
T-cell depletion is commonly used in strategies that attempt to coax the immune system into tolerating foreign tissue after transplantation. Studies in mice now indicate that this depletion may be at odds with the goal of inducing tolerance (pages 87−92).
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