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New Technology
Nature Medicine  1, 967 - 968 (1995)
doi:10.1038/nm0995-967

Complement inhibitory therapeutics and xenotransplantation

Una S. Ryan

T Cell Sciences, Inc., 115 Fourth Avenue, Needham, Massachusetts 02194, USA


REFERENCES
  1. Sandrin, M.S., Vaughan, H.A., Dabkowski, P.L. & McKenzie, I.F.C., IgM antibodies in human serum react predominantly with gal(alpha1−3)gal epitopes. Proc. natn. Acad. Sci. U.S.A. 90, 11391−11395 (1993). | ChemPort |
  2. Bach, F.H., Turman, M.A., Vercellotti, G.M., Platt, J.L. & Dalmasso, A.P. Accommodation: A working paradigm for progressing toward discordant xenografting. Transplantn Proc. 23, 205−208 (1991). | ChemPort |
  3. Baldwin, W.M., Pruitt, S.K., Brauer, R.B., Daha, M.R. & Sanfilippo, F. Complement in organ transplantation. Transplantation 59, 797−808 (1995). | PubMed  | ISI |
  4. Ryan, U.S. Complement inhibition: The sine qua non of xenotransplantation?. Xeno 2, 19−22 (1994).
  5. Thomas, L.J. & Ryan, U.S. Immunological consequences of organ transplantation: Implications for therapeutic development. J. Heart Lung Transplantn (in the press).
  6. Dalmasso, A.P., Vercellotti, G.M., Platt, J.L. & Bach, F.H. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor: Potential for prevention of xenograft hyperacute rejection. Transplantation 32, 530−533 (1991).
  7. McCurry, K.R. et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med. 1, 423−427 (1995). | Article | PubMed  | ISI | ChemPort |
  8. Cozzi, E. & White, D.J.G. The generation of transgenic pigs as potential organ donors for man. Nature Med. 1, 964−966 (1995). | Article | PubMed  | ISI | ChemPort |
  9. Foder, W.L. & Squinto, S.P. Engineering of transgenic pigs for xenogeneic organ transplantation. Xeno 3, 23−25 (1995).
  10. Weisman, H.F. et al. Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 249, 146−151 (1990). | PubMed  | ISI | ChemPort |
  11. Pruitt, S.K. et al. The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. Transplantation 52, 868−873 (1992). | ISI |
  12. Xia, W. et al. Prolongation of guinea pig cardiac xenograft survival in rats by soluble human complement receptor type 1. Transplantn Proc. 24, 479−480 (1992). | ChemPort |
  13. Xia, W., Fearon, D.T. & Kirkman, R.L. Effect on repetitive doses of soluble human complement receptor type 1 on survival of discordant cardiac xenografts. Transplantn Proc. 25, 410−411 (1993). | ChemPort |
  14. Pruitt, S.K. et al. The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts. Transplantation 57, 363−370 (1994). | PubMed  | ISI | ChemPort |
  15. Candinas, D. et al. Soluble complement receptor type 1 and cobra venom factor in discordant xenotransplantation. Transplantn Proc. (in the press).
  16. Pruitt, S.K. et al. Continuous complement (C) inhibition using soluble complement receptor type 1 (sCRI): Effect on hyperacute rejection (HAR) of pig-to-primate cardiac xenografts (Xgs). Transplantn Proc. (in the press).
  17. Bannett, A.D., McAlack, R.F., Raja, R., Baquero, A. & Morris, M. Experiences with known ABO-mismatched renal transplants. Transplantn Proc. XIX, 4543−4546 (1987).
  18. Alexandre, G.P.J. et al. Present experiences in a series of 26 ABO-incompatible living donor renal allografts. Transplantn Proc. XIX, 4538−4542 (1987).
  19. Ryan, U.S., ed. Endothelial Cells I−III (CRCBoca Raton, Florida, 1988).
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