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Article
Nature Genetics  1, 442 - 447 (1995)
doi:10.1038/nm0595-442

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

Scott L. Gottlieb1, Patricia Gilleaudeau1, Ray Johnson1, Len Estes2, Thasia G. Woodworth2, Alice B. Gottlieb1 & James G. Krueger1, 3

  1Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, New York 10021-6399, USA

  2Seragen, Inc., 97 South Street, Hopkinton, Massachusetts 01748, USA

  3Correspondence should be addressed to J.G.K.

Psoriasis is a hyperproliferative and inflammatory skin disorder of unknown aetiology. A fusion protein composed of human interleukin-2 and fragments of diphtheria toxin (DAB389IL-2), which selectively blocks the growth of activated lymphocytes but not keratinocytes, was administered systemically to ten patients to gauge the contribution of activated T cells to the disease. Four patients showed striking clinical improvement and four moderate improvement, after two cycles of low dose IL-2−toxin. The reversal of several molecular markers of epidermal dysfunction was associated with a marked reduction in intraepidermal CD3+ and CD8+ T cells, suggesting a primary immunological basis for this widespread disorder.

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ISSN: 1078-8956
EISSN: 1546-170X
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