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Nature Genetics  1, 416 (1995)
doi:10.1038/nm0595-416

CRH, a placental clock and preterm labour

John R.G. Challis

Lawson Research Institute, St. Joseph's Health Centre, London, Ontario N6A 4V2, Canada

The existence of a placental clock controlling the term of pregnancy has long been hypothesized. Now scientists may have uncovered what makes it tick (pages 460−463).

REFERENCES
  1. Challis, J.R.G. & Mitchell, M.D. Basic mechanisms of pre-term labour. Res. clin. Forums 16, 39−58 (1994).
  2. Casey, M.L. & MacDonald, P.C. The role of prostaglandins in labour. in NIH Workshop on Initiation of Labour (eds MacDonald, P.C., Challis, J.R. G., Roberts, J.M. & Nathanielsz, P.W.) 141−156 (Perinatology Press, Ithaca, New York, 1988).
  3. Campbell, E.A. et al. Plasma corticotropin-releasing hormone concentrations during pregnancy and parturition. J. clin. Endocrin. Metabol. 64, 1054−1059 (1987). | ISI | ChemPort |
  4. Perkins, A.V., Eben, F., Wolfe, C.D.A., Schulte, H.M. & Linton, E.A. Plasma measurements of corticotrophin-releasing hormone-binding protein in normal and abnormal human pregnancy. J. Endocrin. 138, 149−157 (1993). | ISI | ChemPort |
  5. McLean, M. et al. A placental clock controlling the length of human pregnancy. Nature Med. 1, 460−463 (1995). | Article | PubMed  | ISI | ChemPort |
  6. Thorburn, G.D. & Rice, G.E. Placental PGE2 and the initiation of parturition in the sheep. in Eicosanoids in Reproduction (ed. Mitchell, M.D.) 73−86 (CRC Press, Boca Raton, Florida, 1990).
  7. Wolfe, C.D.A. et al. Plasma corticotrophin-releasing factor (CRF) in abnormal pregnancy. Brit. J. Obstet. Gyn. 95, 1003−1006 (1988). | ISI | ChemPort |
  8. Challis, J.R.G. & Hooper, S. Birth: Outcome of a positive cascade. in Perinatal Endocrinology (ed. Jones, C.T.) 781−793 (Saunders, New York, 1989). | ChemPort |
  9. Warren, W.B., Patrick, S.L. & Goland, R.S. Elevated maternal plasma corticotropin-releasing hormone levels in pregnancies complicated by pre-term labour. Am. J. Obstet. Gynecol. 166, 1198−1204 (1992). | PubMed  | ISI | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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