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Nature Medicine  1, 403 - 404 (1995)
doi:10.1038/nm0595-403

Nudging xenotransplantation towards humans

John W. Fabre

Institute of Child Health University of London London WC1N 1EH, UK

Transplanting organs across species lines presents tremendous difficulties, but the obstacles are no longer insurmountable (pages 423−427).

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  3. von Decastello, A. Ueber experimentelle nierentransplantation. Wiener Klinische Wochenschrift 12, 317 (1902).
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  8. Galili, U. Interaction of the natural anti-Gal antibody with a-galactosyl epitopes: A major obstacle for xenotransplantation in humans. Immun. Today 14, 480−482 (1993). | Article | PubMed  | ISI | ChemPort |
  9. Inverardi, L. & Pardi, R. Early events in cell-mediated recognition of vascularised xenografts: Cooperative interactions between selected lymphocyte subsets and natural antibodies. Immunol. Rev. 141, 71−93 (1994). | PubMed  | ISI | ChemPort |
  10. Sandrin, M.S., Vaughan, H.A., Dabkowski, P.L. & McKenzie, I.F.C. IgM antibodies in human serum react predominantly with Gal(a1-3)Gal epitopes. Proc. natn. Acad. Sci. U.S.A. 90, 11391−11395 (1993). | ChemPort |
  11. Gustafsson, K., Strahan, K. & Preece, A. a1,3 Galactosyltransferase: A target for in vivo genetic manipulation in xenotransplantation. Immunol. Rev. 141, 59−70 (1994). | PubMed  | ISI | ChemPort |
  12. Sawyer, G.J., Gustafsson, K. & Fabre, J.W. Vascularised mouse-to-rat heart grafts: An unexpectedly difficult model of xenotransplantation. Transplantation Proc. 27 309 (1995). | ISI | ChemPort |
  13. Ullman, E. Tissue and organ transplantation. Ann. Surg. 60, 195−219 (1914).
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ISSN: 1078-8956
EISSN: 1546-170X
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