HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques
Alash'le G. Abimiku1, Genoveffa Franchini1, James Tartaglia2, Kristine Aldrich1, Maria Myagkikh1, Phillip D. Markham3, Pele Chong4, Michel Klein4, Marie-Paule Kieny5, Enzo Paoletti2, Robert C. Gallo1
& Marjorie Robert-Guroff1, 6
1Laboratory of Tumor Cell Biology, Building 37, Room 6A09, 37 Convent Drive MSC 4255. National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
2Virogenetics Corporation, 465 Jordan Road, Rensselaer Technology Park, Troy, New York 12180, USA
5Transgene, 11 rue de Molsheim, 67082 Strasbourg, France
6Correspondence should be addressed to M.R.G.
Rhesus macaques were immunized with attenuated vaccinia or canarypox human immunodeficiency virus type 1 (HIV-1) recombinants and boosted with HIV-1 protein subunits formulated in alum. Following challenge with HIV-2SBL6669, three out of eight immunized macaques resisted infection for six months and another exhibited significantly delayed infection, whereas all three naive controls became infected. Immunizations elicited both humoral and cellular immune responses; however, no clear correlates of protection were discerned. Although more extensive studies are now called for, this first demonstration of cross-protection between HIV-1 and -2 suggests that viral variability may not be an insurmountable problem in the design of a global AIDS vaccine.
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