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Nature Medicine  1, 305 - 306 (1995)
doi:10.1038/nm0495-305

Filling in the matrix of kidney disease

Robert Bacallao1

1Departments of Medicine and Cellular and Molecular Biology, Northwestern University Medical School Chicago, Illinois 60611, USA

The discovery of a gene associated with autosomal dominant polycystic kidney disease (ADPKD) was only the first step toward understanding the disease. Now researchers are determining what the gene' product normally does (pages 359−364).

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  7. van Adelsberg, J.S. & Frank, D. The PKD1 gene produces a developmentally regulated protein in mesenchyme and vasculature. Nature Med. 1, 359−364 (1995). | Article | PubMed  | ChemPort |
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  9. Wilson, P. D. & Burrow, C.R. Autosomal dominant polcystic kidney disease: cellular and molecular mechanisms of cyst formation. Adv. Nephr. 21, 125−142 (1992). | ChemPort |
  10. Bacallao, R., Nakamura, S. & Carone, F.A. Intermediate filament expression suggests a block in the differentiation pathway of ADPDK epithelial cells [Abstract]. J.A.S.N. 4, 881 (1993).
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  13. Wilson, P.D., Du, J. & Norman, J.T., tocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease. Euro. J cell Biol. 61, 131−138 (1993). | ISI | ChemPort |
  14. Carone, F.A., Jin, H., Nakamura, S. & Kanwar, Y.S. Decreased synthesis and delayed processing of sulfated glycoproteins by cells from human polycystic kidneys. Lab. Invest. 68, 413−418, (1993). | PubMed  | ISI | ChemPort |
  15. Wilson, P.D. et al. Reversed polarity of Na(+)-K(+)-ATPase: misiocation to apical plasma membranes in polycystic kidney disease epithelia. Am. J. Physiol. 260, F420−F430 (1991). | PubMed  | ISI | ChemPort |
  16. Ye, M. & Grantham, J. J. The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease. New Engl. J. Med. 329, 310−313 (1993). | Article | PubMed  | ISI | ChemPort |
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  18. Bacallao, R., Carone, F.A., Nakamura, S. & Wandinger-Ness, A. Evidence for a Golgi complex defect in autosomal dominant polycystic kidney disease (ADPKD) [Abstract] J.A.S.N. 5, 618 (1994).
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ISSN: 1078-8956
EISSN: 1546-170X
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