Nature Medicine
1, 305 - 306 (1995)
doi:10.1038/nm0495-305
Filling in the matrix of kidney diseaseRobert Bacallao1
1Departments of Medicine and Cellular and Molecular Biology, Northwestern University Medical School Chicago, Illinois 60611, USA The discovery of a gene associated with autosomal dominant polycystic kidney disease (ADPKD) was only the first step toward understanding the disease. Now researchers are determining what the gene' product normally does (pages 359−364). REFERENCES
- Grantham, J.J. & Gabow, P.A. Polycystic kidney Diseases. In Diseases of the Kidney (eds Schrier, R. W. & Gottschalk, C. W.) 583−616 (Little, Brown and Co., Boston, 1988).
- Levine, E. & Grantham, J.J. The role of computed tomography in the evaluation of adult polycystic kidney disease. Am. J. kidney Dis. 1, 99−105 (1981). | PubMed | ISI | ChemPort |
- Segal, A.J. & Spataro, R.F. Computed tomography of adult polycystic disease. J. Comput. Assist. Tomography 6, 777−780 (1982). | ISI | ChemPort |
- Dalgaard, O. Z. Bilateral polycystic disease of the kidneys. A follow-up of two hundred and eighty-four patients and their families. ACTA Med. Scand. 328 (Supplement), 1−251 (1957).
- Germino, G. G. et al. Identification of a locus which shows no genetic recombination with the autosomal dominant polycystic kidney disease gene on chromosome 16. Am. J. hum. genet. 46, 925−933 (1990). | PubMed | ISI | ChemPort |
- European Polycystic kidney Disease Consortium. The Polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. Cell 77, 881−894 (1994). | PubMed | ISI |
- van Adelsberg, J.S. & Frank, D. The PKD1 gene produces a developmentally regulated protein in mesenchyme and vasculature. Nature Med. 1, 359−364 (1995). | Article | PubMed | ChemPort |
- Carone, F. A., Rowland, R. G., Perlman, S. G. & Ganote, C.E. The pathogenesis of drug-induced renal cystic disease. 5, 411−421 (1974). | ChemPort |
- Wilson, P. D. & Burrow, C.R. Autosomal dominant polcystic kidney disease: cellular and molecular mechanisms of cyst formation. Adv. Nephr. 21, 125−142 (1992). | ChemPort |
- Bacallao, R., Nakamura, S. & Carone, F.A. Intermediate filament expression suggests a block in the differentiation pathway of ADPDK epithelial cells [Abstract]. J.A.S.N. 4, 881 (1993).
- Burrow, C.R., Gatti, L., Hartz, P. & Wilson, P.O. Expression of fetal proteins in human polcystic kidney disease (PKD) epithelia [Abstract]. J.A.S.N. 4, 813 (1993).
- Wilson, P.D. Aberrant epithelial cell growth in autosomal dominant polycystic kidney disease. Am. J. kidney Dis. 17, 634−637, (1991). | PubMed | ISI | ChemPort |
- Wilson, P.D., Du, J. & Norman, J.T., tocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease. Euro. J cell Biol. 61, 131−138 (1993). | ISI | ChemPort |
- Carone, F.A., Jin, H., Nakamura, S. & Kanwar, Y.S. Decreased synthesis and delayed processing of sulfated glycoproteins by cells from human polycystic kidneys. Lab. Invest. 68, 413−418, (1993). | PubMed | ISI | ChemPort |
- Wilson, P.D. et al. Reversed polarity of Na(+)-K(+)-ATPase: misiocation to apical plasma membranes in polycystic kidney disease epithelia. Am. J. Physiol. 260, F420−F430 (1991). | PubMed | ISI | ChemPort |
- Ye, M. & Grantham, J. J. The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease. New Engl. J. Med. 329, 310−313 (1993). | Article | PubMed | ISI | ChemPort |
- Grantham, J. J. Polycystic kidney disease: neo-plasia in disguise. [Review]. Am. J. kidney Dis. 15, 110−116 (1990). | PubMed | ISI | ChemPort |
- Bacallao, R., Carone, F.A., Nakamura, S. & Wandinger-Ness, A. Evidence for a Golgi complex defect in autosomal dominant polycystic kidney disease (ADPKD) [Abstract] J.A.S.N. 5, 618 (1994).
|