Nature Medicine
1, 304 - 305 (1995)
doi:10.1038/nm0495-304
CTL to HIV-1: Surrogates or sirensBonnie J. Mathieson1
1Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892, USA The generation of cytotoxic T lymphocyte response may be an essential part of an effective immune response to HIV infection. It may also do more harm than good (pages 330−336).
REFERENCES
- Koenig, S. et al. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nature Med. 1, 330−336 (1995). | Article | PubMed | ISI | ChemPort |
- Koup, R. et al. Temporal association of cellular responses with the initial control of viremia in primary HIV-1 syndrome. J. Virol. 68, 4650−4655 (1994). | PubMed | ISI | ChemPort |
- Borrow, P., Lewicki, H., Hahn, B.H., Shaw, G.M. & Oldstone, M.B. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68, 6103−6110 (1994). | PubMed | ISI | ChemPort |
- Yasutomi, Y., Reiman, K., Lord, C., Miller, M. & Letvin, N. Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys. J. Virol. 67, 1707−1711 (1993). | PubMed | ISI | ChemPort |
- Cheynier, R. et al. Cytotoxic T lymphocyte responses in the peripheral hlood of children born to HIV-1-infected mothers. Eur. J. Immunol. 22, 2211−2217 (1992). | PubMed | ISI | ChemPort |
- Rowland-Jones, S.L. et al. HIV-specific CTL activity in an HIV-exposed but uninfected infant. Lancet 341, 860−861 (1993). | Article | PubMed | ChemPort |
- Aldhous, M.C., Watret, K.C., Mok, J.Y., Bird, A.G. & Froebel, K.S. Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection. Clin. exp. Immunol. 97, 61−67 (1994). | PubMed | ISI | ChemPort |
- Langlade-Demoyen, P., Ngo-Giang-Huong, N., Ferchal, F. & Oksenhendler, E. HIV nef-specific cytotoxic T lymphocytes in noninfected heterosexual contacts of HIV-infected patients. J. clin. Investig. 93, 1293−1297 (1994). | PubMed | ChemPort |
- Rowland−Jones, S. et al. HIV−specific cytotoxic T−cells in HIV−exposed but uninfected Gambian women. Nature Med. 1, 59−64 (1995). | Article | PubMed | ISI |
- Johnson, R.P., Trocha, A., Buchanan, D.M. & Walker, B.D. Identification of overlapping HLA class I−restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: Definition of minimum epitopes and analysis of the effects of sequence variation. J. exp. Med. 175, 961−971 (1992). | PubMed | ISI | ChemPort |
- Keet, I.P.M. et al. Characteristics of long-term asymptomatic infection with human immunodeficiency virus type 1 in men with normal and low CD4+ cell counts. J. infect. Dis. 169, 1236−1243 (1994). | PubMed | ISI | ChemPort |
- Schrager, L.K., Young, J.M., Fowler, M.G., Mathieson, B.J. & Vermund, S.H. Long-term survivors of HIV-1 infection: definitions and research challenges. AIDS 8 (suppl 1), S95−S108 (1994). | PubMed |
- Gotch, F.M., Nixon, D.F., Alp, N., McMichael, A.J. & Borysiewicz, L.K. High frequency of memory and effector gag-specific cytotoxic T lymphocyte in HIV seropositive individuals. Intl. Immun. 2, 707−712 (1990). | ChemPort |
- Lieberman, J. et al. Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in gp160 and reverse transcriptase. J. Immun. 148, 2738 (1992). | PubMed | ISI | ChemPort |
- Jassoy, C. et al. Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-
 ), and TNF- when they encounter their target antigens. J. Virol. 67, 2844−2852 (1993). | PubMed | ISI | ChemPort |
- Lohman, B.L. et al. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J. Virol. 68, 7021−7029 (1994). | PubMed | ISI | ChemPort |
- Shen, L. et al. Recombinant virus vaccine-induced SIV-specific CD8+ cytotoxic T lymphocytes. Science 252, 440−443 (1991). | PubMed | ISI | ChemPort |
- Hammond, S.A. et al. Comparative clonal analysis of human immunodeficiency virus type 1 (HlV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HIV-1 vaccines. J. exp. Med. 176, 1531−1542 (1992). | PubMed | ISI | ChemPort |
- Yasutomi, Y. et al. Immunization with recombinant BCG-SIV elicits SIV-specific cytotoxic T lymphocytes in rhesus monkeys. J. Immun. 150, 3101−3107 (1993). | PubMed | ISI | ChemPort |
- Aldovini, A. & Young, R.A. Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines. Nature 351, 479−482 (1991). | Article | PubMed | ISI | ChemPort |
- Miller, M.D. et al. Vaccination of rhesus monkeys with synthetic peptide in a fusogenic proteoliposome elicits simian immunodeficiency virus−specific CD8+ cytotoxic T lymphocytes. J. exp. Med. 176, 1739−1744 (1992). | PubMed | ISI | ChemPort |
- Newman, M. et al. Induction of antigen−specific killer T lymphocyte responses using subunit SIV-mac251 gag and env vaccines containing QS-21 saponin adjuvant. AIDS Res. human Retrovir 10, 853−861 (1994). | ISI | ChemPort |
- Wang, B. et al. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. natn. Acad. Sci. 90, 4156−4160 (1993). | ChemPort |
- Kalams, S.A. et al. Longitudinal analysis of TCR gene usage by HIV-1 envelope-specific CTL clones reveals a limited TCR repertoire. J. exp. Med. 179, 1261−1271 (1994). | PubMed | ISI | ChemPort |
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