Nature Medicine
1, 300 - 302 (1995)
doi:10.1038/nm0495-300
Molecular DIY with hairpins and hammerheadsSaghir Akhtar1, Helen James1
& Ian Gibson2
1Pharmaceutical Sciences Institute, Aston University, Birmingham B4 7ET, UK
2School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK Ribozymes can inhibit gene expression in a sequence-specific manner by catalysing cleavage of target messenger RNAs. They can also be used to for DIY (do-it-yourself) surgery on defective RNAs. The potential therapeutic applications of these ribozyme properties were discussed at a recent meeting.
REFERENCES
- Pley, H.W., Flaherty, K.M. & Mckay, D.B. Three-dimensional structure of a hammerhead ribozyme. Nature 372, 68−74 (1994). | Article | PubMed | ISI | ChemPort |
- Akhtar, S. & Juliano, R.L. Cellular uptake and intracellular fate of antisense oligonucleotides. Trends cellBiol. 2, 139−144 (1992). | Article | ChemPort |
- Elkins, D.A. & Rossi, J.J. Cellular Delivery of ribozymes in Delivery Strategies for Antisense Oligonucleotide Therapeutics (ed. Akhtar, S.) (CRC Press, Boca Raton, Florida, USA, 1995).
|
