Nature Medicine
1, 207 - 208 (1995)
doi:10.1038/nm0395-207
Agalactosyl IgG and mannose-binding proteins: Biochemical nicety or pathophysiological paradigm?R. Alan B. Ezekowitz1
1Division of Hematology and Infectious Diseases, Harvard Department of Pediatrics Children's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA It is unclear whether modified immunoglobulins are at least partially responsible for rheumatoid arthritis (pages 237−243) or only an effect of the disease. REFERENCES
- Malhotra, R., Wormald, M.R., Rudd, P.M., Fischer, P.B., Dwek, R.A. & Sim, R.B. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nature Med. 1, 237−243 (1995). | Article | PubMed | ISI | ChemPort |
- Parekh, R.B. et al. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 316, 452−457 (1985). | PubMed | ISI | ChemPort |
- Drickamer, K. & Taylor, M.E. Biology of animal lectins. Annu. Rev. Cell Biol. 9, 237−264 (1993). | PubMed | ISI | ChemPort |
- Lu, J.H., Thiel, S., Wiedmann, H., Timpl, R. & Reid, K.B. Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex of the classical pathway of complement without involvement of C1q. J. Immun. 144, 2287−2294 (1990). | PubMed | ISI | ChemPort |
- Ezekowitz, R.A.B. Ante-antibody immunity. Current Biol. 1, 60−62 (1991). | ChemPort |
- Sastry, K. & Ezekowitz, R.A.B. Collectins: pattern recognition molecules involved in first line host defense. Curr. Opin. Immun. 5, 59−66 (1993). | Article | ISI | ChemPort |
- Schweinle, J., Ezekowitz, R.A.B., Tenner, A. & Joiner, K. Human mannose-binding protein activates the alternative complement pathway and enhances serum bactericidal activity on a man-nose-rich isolate of Salmonella. J. clin. Invest. 84, 1821−1829 (1989). | PubMed | ISI | ChemPort |
- Ikeda, K., Sannoh, T., Kawasaki, N., Kawasaki, T. & Yamashina, I. Serum lectin with known structure activates complement through the classical pathway. J. biol. Chem. 262, 7451 (1987). | PubMed | ISI | ChemPort |
- Matsushita, M. & Fujita, T. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J. exp. Med. 176, 1497−1502 (1992). | PubMed | ISI | ChemPort |
- Weis, W.I., Drickamer, K. & Hendrickson, W.A. Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature 360, 127−134 (1992). | Article | PubMed | ISI | ChemPort |
- Super, M. et al. Distinct and overlapping functions of allelic forms of human mannose-binding protein. Nature Genet. 2, 50−55 (1992). | PubMed | ISI | ChemPort |
- Super, M., Thiel, S., Lu, J. & Turner, M.W. Association of low levels of mannan-binding protein with a common defect of opsonization. Lancet ii (8674), 1236−1238 (1989). | Article |
- Hartshorn, K.L. et al. Human mannose-binding protein serves as an opsonin for influenza A. J. Clin. Invest. 91, 1414−1420 (1993). | PubMed | ISI | ChemPort |
- Anders, E.M., Hartley, C.A., Reading, P.C. & Ezekowitz, R.A.B. Complement-dependent neutralization of influenza virus by a serum mannose-binding lectin. J. gen. Virol. 75, 615−622 (1994). | PubMed | ISI | ChemPort |
- Duncan, A.R. & Winter, G. The binding site for C1q on IgG. Nature 332, 738−740 (1988). | Article | PubMed | ISI | ChemPort |
- Sheriff, S., Chang, C.Y. & Ezekowitz, R.A.B. Human mannose-binding protein carbohydrate recognition domain trimerizes through triple
-helical coiled-coil. Nature struct Biol. 1, 789−794 (1994). | PubMed | ISI | ChemPort |
- Weis, W.I. & Drickamer, K. Trimeric structure of a C-type mannose-binding protein. Current Biol. 2, 1227−1240 (1994). | ChemPort |
- Sumiya, M. et al. Molecular basis of opsonic defect in immunodeficient children. Lancet 337, 1569−1570 (1991). | Article | PubMed | ISI | ChemPort |
- Matsushita, M., Ezekowitz, R.A.B. & Fujita, T. An allelic form of human mannose-binding protein (MBP) fails to bind to mannose-binding protein-associated serine protease (MASP). (submitted).
- Madsen, H.O. et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 40, 37−44 (1994). | PubMed | ISI | ChemPort |
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