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Nature Medicine  1, 205 - 206 (1995)
doi:10.1038/nm0395-205

A peppy response to PEPI results

Loretta P. Finnegan1, Jacques Rossouw1 & William R. Harlan1

1Woman's Health Initiative, Office of Research on Women's Health Office ofDisease Prevention National Insitutes of Health Bethesda, Maryland 20892-9110, USA

Recent publication of the results of the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial has led to the Woman's Health Initiative(WHI) to rethink the protocols for its own large trial.

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  2. Grady, D. et al Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann. intern. Med., 117, 1016−1037 (1992). | PubMed  | ISI | ChemPort |
  3. Wentz, W.B. Progestin therapy in endometrial hyperplasia. Gynecol. Oncol. 2, 362−367 (1974). | Article | PubMed  | ChemPort |
  4. Smith, D.C., Prentice, R., Donovan, J.T. & Herrman, W.L. Association of exogenous estrogen and endometrial carcinoma. New Engl. J. Med. 293, 1164−1167 (1975). | PubMed  | ISI | ChemPort |
  5. Ziel, H.K. & Finkle, W.D. Increased risk of endometrial carcinoma among users of conjugated estrogens. New Engl. J. Med. 293, 1167−1170 (1975). | PubMed  | ISI | ChemPort |
  6. ACOG Technical Bulletin 166 (American College of Obstetricians and Gynecologists, Washington, DC, 1992).
  7. American College of Physicians. Ann. intern. Med. 117, 1038−1041 (1992). | ISI |
  8. Woodruff, J.D. & Pickar, J.H. Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone. The Menopause Study Group. Am. J. Obstet. Gynecol. 170, 1213−1223 (1994). | PubMed  | ISI | ChemPort |
  9. Simon, J.A. et al. The absorption of micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone. Obstet. Gynecol. 60, 26−33 (1993). | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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