Nature Medicine
1, 117 - 118 (1995)
doi:10.1038/nm0295-117
Tumour dormancy: not so sleepy after allCliff Murray1
1Laboratory of Molecular Oncology, CRC Department of Clinical Oncology, City Hospital, Nottingham NG5 1PB, UK Removal of a primary tumour can result in a burst of growth in previously 'dormant' micrometastases and is associated with onset of angiogenesis and a reduced incidence of apoptosis (see pages 149−153)
REFERENCES
- Holmgren, L., O'Reilly, M.S. & Folkman, J. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med. 1, 149−153 (1995) | Article | PubMed | ISI | ChemPort |
- Folkman, J., Merler, E., Abernathy, C. & Williams, G. Isolation of a tumour factor responsible for angiogenesis. J. exp. Med. 133, 275−288 (1971). | PubMed | ISI | ChemPort |
- Folkman, J. Tumor angiogenesis: Therapeutic implications. New. Engl. J. Med. 285, 1182−1186 (1971). | PubMed | ISI | ChemPort |
- Folkman, J. What is the evidence that tumors are angiogenesis dependent. J. natl. Cancer Inst. 82, 4−6 (1990). | Article | PubMed | ChemPort |
- Kim, K.J., et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362, 841−844 (1993). | Article | PubMed | ISI | ChemPort |
- Hori, A. et al. Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor. Cancer Res. 51, 6180−6184 (1991). | PubMed | ISI | ChemPort |
- Rastinejad, F., Polverini, P. & Bouk, N.P. Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene. Cell 56, 345−355 (1989). | Article | PubMed | ISI | ChemPort |
- Dameron, K.M., Volpert, K.V., Tainsky, M.A. & Bouk, N.P. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265, 1582−1584 (1994). | PubMed | ISI | ChemPort |
- Van Meir, E.G., et al. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature Genet. 8, 171−176 (1994). | PubMed | ChemPort |
- O'Reilly, M.S., et al. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315−328 (1994). | Article | PubMed | ChemPort |
- Weinstat-Saslow, D.L. et al. Transfection of thombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, mestastatic potential, angiogenesis. Cancer Res. 54, 6504−6511 (1994). | PubMed | ChemPort |
- Demicheli, R., et al. Local recurrences following mastectomy: Support for the concept of tumor dormancy. J. natl. Cancer Inst. 86, 45−48 (1994). | PubMed | ChemPort |
- Weidner, N., Semple, J., Welch, W. & Folkman, J. Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. New. Engl. J. Med. 324, 1−8 (1991). | PubMed | ISI | ChemPort |
- Fox, S.B. et al. relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res. 53, 4161−4163 (1993). | PubMed | ISI | ChemPort |
- Schultz-Hector, S. & Haghayegh, S.
 -Fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation. Cancer Res. 53, 1444−1449 (1993). | PubMed | ChemPort |
- Kandel, J. et al. Neovascularization is associated with a switch to the export of bFGF in the multi-step development of fibrosarcoma. Cell 66, 1095−1104 (1991). | Article | PubMed | ISI | ChemPort |
- Shweiki, D., Itin, A., Soffer, D. & Keshet, E. Vascular endothelial growth factor induced by hy-poxia may mediate hypoxia-initiated angio-genessis. Nature 359, 843−845 (1992). | Article | PubMed | ISI | ChemPort |
- Plate, K.H., Breier, G., Weich, H.A. & Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359, 845−848 (1992). | Article | PubMed | ISI | ChemPort |
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