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Nature Medicine  1, 1130 - 1131 (1995)
doi:10.1038/nm1195-1130

No bones about fluoride

Gregory R. Mundy

Department of Medicine/Endocrinology & Metabolism, University of Texas Health Science Center, San Antonio, Texas 78284, USA

We now have a number of effective drugs for osteoporosis. However, close inspection of clinical trials results suggests we should aim for even better ones.

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  2. Riggs, B.L. et al. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. New Engl. J. Med. 322, 802−809 (1990). | PubMed  | ISI | ChemPort |
  3. Kleerekoper, M. et al. A randomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis. Osteoporosis Int. 1, 155−161 (1991). | ChemPort |
  4. Lau, K.H., Farley, J.R., Freeman, T.K. & Baylink, D.J. A proposed mechanism of the mitogenic action of fluoride on bone cells: Inhibition of the activity of an osteoblastic acid phosphatase. Metabolism 38, 858−868 (1989). | Article | PubMed  | ISI | ChemPort |
  5. Reeve, J. et al. Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: A multicentre trail. Br. Med. J. 280, 1340−1344 (1980). | PubMed  | ISI | ChemPort |
  6. Grigoriadis, A.E. et al. c-fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443−448 (1994). | PubMed  | ISI | ChemPort |
  7. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693−702 (1991). | PubMed  | ISI | ChemPort |
  8. Chavassieux, P.M., Arlot, M.E. & Meunier, P.J. Intersample variation in bone histomorphometry: Comparison between parameter values measured on two contiguous transiliac bone biopsies. Calcif. Tissue Int. 37, 345−350 (1985). | PubMed  | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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