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In the last few years, the Nature Publishing Group has published numerous papers on mechanisms of atherogenesis and potential therapeutic targets for intervention. This list, presented in reverse chronological order, will take you directly to those papers (available free until 31 January 2003 online).
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
A. Luttun, M. Tjwa, L. Moons, Y. Wu, A. Angelillo-Scherrer, F. Liao, J.A. Nagy, A. Hooper, J.Priller, B. De Klerck, V. Compernolle, E. Daci, P. Bohlen, M. Dewerchin, J.M. Herbert, R. Fava, P. Matthys, G. Carmeliet, D. Collen, H.F. Dvorak, D.J. Hicklin, P. Carmeliet doi:10.1038/nm731
Nature Medicine 2002 Aug;8(8):831—840.Abstract | Full Text | PDF
Kr�ppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
T. Shindo, I. Manabe, Y. Fukushima, K. Tobe, K. Aizawa, S. Miyamoto, K. Kawai-Kowase, N. Moriyama, Y. Imai, H. Kawakami, H. Nishimatsu, T. Ishikawa, T.Suzuki, H. Morita, K. Maemura, M. Sata, Y. Hirata, M. Komukai, H. Kagechika, T. Kadowaki, M. Kurabayashi, R. Nagai doi:10.1038/nm738
Nature Medicine 2002 Aug;8(8):856—863.Abstract | Full Text | PDF
Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis
M. Sata, A. Saiura, A. Kunisato, A. Tojo, S. Okada, T. Tokuhisa, H. Hirai, M. Makuuchi, Y. Hirata, R. Nagai doi:10.1038/nm0402-403
Nature Medicine 2002 Apr;8(4):403—409.Abstract | Full Text | PDF
CD40L stabilizes arterial thrombi by a β3 integrin-dependent mechanism
P. Andr�, K.S.S. Prasad, C.V. Denis, M. He, J.M. Papalia, R.O. Hynes, D.R. Phillips, D.D. Wagner doi:10.1038/nm0302-247
Nature Medicine 2002 Mar;8(3):1318—20.Abstract | Full Text | PDF
CD99 plays a major role in the migration of monocytes through endothelial junctions
A.R. Schenkel, Z.Mamdouh, X. Chen, R.M. Liebman, W.A. Muller
doi:10.1038/ni749
Nature Immunology 2000 Feb;3(2):143—150.Abstract | Full | PDF
The potential for novel anti-inflammatory therapies for coronary artery disease
M.A. Cascieri doi:10.1038/nrd723
Nature Reviews Drug Discovery 2002 Feb;1(2):122—130.
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SCAP ligands are potent new lipid-lowering drugs
T. Grand-Perret, A. Bouillot, A. Perrot, S. Commans, M. Walker, M. Issandou doi:10.1038/nm1201-1332
Nature Medicine 2001 Dec;7(12):1332—1338.Abstract | Full | PDF
A new feature on the cholesterol-lowering landscape
D.J. Rader doi:10.1038/nm1201-1282 Nature Medicine 1997 Dec;7(12):1282-—1284.
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Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency
X.C. Jiang, S. Qin, C. Qiao, K. Kawano, M. Lin, A. Skold, X. Xiao, A.R. Tall doi:10.1038/89977
Nature Medicine 2001 Jul;7(7):847—852.
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High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
I.S. Yuhanna, Y.Zhu, B.E. Cox, L.D. Hahner, S. Osborne-Lawrence, P. Lu, Y.L. Marcel, R.G.W. Anderson, M.E. Mendelsohn, H.H. Hobbs, P.W. Shaul doi:10.1038/89986
Nature Medicine 2001 Jul;7(7):853—857.
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A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation
E. Griffin, A. Re, N. Hamel, C. Fu, H. Bush, T. McCaffrey, A.S. Asch doi:10.1038/89969
Nature Medicine 2001 Jul;7(7):840—846.
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Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
C. Heeschen, J.J. Jang, M. Weis, A. Pathak, S. Kaji, R.S. Hu, P.S. Tsao, F.L. Johnson, J.P. Cooke doi:10.1038/89961
Nature Medicine 2001 Jul;7(7):833—839.
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Lipid mediator class switching during acute inflammation: signals in resolution
B.D. Levy, C.B. Clish, B. Schmidt, K. Gronert, C.N. Serhan doi:10.1038/89759
Nature Immunology 2001 Jul;2(7):612—619.
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Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy
K. Shimizu, S. Sugiyama, M. Aikawa, Y. Fukumoto, E. Rabkin, P. Libby, R.N. Mitchell doi:10.1038/89121
Nature Medicine 2001 Jun;7(6):738—741.
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Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair
H. Jeon, W. Meng, J. Takagi, M.J. Eck, T.A. Springer, S.C. Blacklow doi:10.1038/88556
Nature Structural Biology 2001 Jun;8(6):499—504.
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Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
L. Makowski, J.B. Boord, K. Maeda, V.R. Babaev, K.T. Uysal, M.A. Morgan, R.A. Parker, J. Suttles, S. Fazio, G.S. Hotamisligil, M.F. Linton doi:10.1038/89076
Nature Medicine 2001 Jun;7(6):699—705.
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Vascular endothelial growth factor enhances atherosclerotic plaque progression
F.L. Celletti, J.M. Waugh, P.G. Amabile, A. Brendolan, P.R. Hilfiker, M.D. Dake doi:10.1038/86490
Nature Medicine 2001 Apr;7(4):425—429.
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Too many vessels? Not enough? The wrong kind? The VEGF debate continues.
J.A. Ware doi:10.1038/86452
Nature Medicine 2001 Apr;7(4):403—404.
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Circulating smooth muscle progenitor cells contribute to atherosclerosis
A. Saiura, M. Sata, Y. Hirata, R. Nagai, M. Makuuchi doi:10.1038/86394
Nature Medicine 2001 Apr;7(4):382—383.
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PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
G. Chinetti, S. Lestavel, V. Bocher, A.T. Remaley, B. Neve, I. Pineda Torra, E. Teissier, A. Minnich, M. Jaye, N. Duverger, H.B. Brewer, J.C. Fruchart, V. Clavey, B. Staels doi:10.1038/83348
Nature Medicine 2001 Jan;7(1):53—58.
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Progress in cardiovascular biology: PPAR for the course
M.A. Lazar doi:10.1038/83301
Nature Medicine 2001 Jan;7(1):23—24.
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PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
A. Chawla, Y. Barak, L. Nagy, D. Liao, P. Tontonoz, R.M. Evans doi:10.1038/83336
Nature Medicine 2001 Jan;7(1):48—52.
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The role of PPAR-gamma in macrophage differentiation and cholesterol uptake
K.J. Moore, E.D. Rosen, M.L. Fitzgerald, F. Randow, .P. Andersson, D. Altshuler, D.S. Milstone, R.M. Mortensen, B.M. Spiegelman, M.W. Freeman doi:10.1038/83328
Nature Medicine 2001 Jan;7(1):41—47.
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Immunomodulation: a new role for statins?
W. Palinski doi:10.1038/82107
Nature Medicine 2000 Dec;6(12):1311—1312.
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Atherosclerosis
A.J. Lusis doi:10.1038/35025203
Nature 2000 Sep;407(9):233—241.
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Molecular multitasking: statins lead to more arteries, less plaque
M. Simons doi:10.1038/79646
Nature Medicine 2000 Sep;6(9):965—966.
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A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
H. Okamoto, F. Yonemori, K. Wakitani, T. Minowa, K. Maeda, H. Shinkai doi:10.1038/doi
Nature 2000 Jul;406(7):203—207.
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Mechanisms of angiogenesis and arteriogenesis
P. Carmeliet doi:10.1038/74651
Nature Medicine 2000 Apr;6(4):389—395.
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Interferon- elicits arteriosclerosis in the absence of leukocytes
G. Tellides, D.A. Tereb, N.C. Kirkiles-Smith, R.W. Kim, J.H. Wilson, J.S. Schechner, M.I. Lorber, J.S. Pober doi:10.1038/35003221
Nature 2000 Jan;403(1):207—211.
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Remodeling of an acellular collagen graft into a physiologically responsive neovessel
T. Huynh, G. Abraham, J. Murray, K. Brockbank, P.O. Hagen, S. Sullivan doi:10.1038/15062
Nature Biotechnology 1999 Nov;17(11):1083—1086.
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Requirement for CD154 in the progression of atherosclerosis
E. Lutgens, L. Gorelik, M.J.A.P. Daemen, E.D. de Muinck, I.S. Grewal, V.E. Koteliansky, R.A. Flavell doi:10.1038/15271
Nature Medicine 1999 Nov;5(11):1313—1316.
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MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
R.E. Gerszten, E.A. Garcia-Zepeda, Y.C. Lim, M. Yoshida, H.A. Ding, M.A. Gimbrone, A.D. Luster, F.W. Luscinskas, A. Rosenzweig doi:10.1038/19546
Nature 1999 Apr;22(4):718—723.
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A novel endothelial-derived lipase that modulates HDL metabolism
M. Jaye, K.J. Lynch, J. Krawiec, D. Marchadier, C. Maugeais, K. Doan, V. South, D. Amin, M. Perrone, D.J. Rader doi:10.1038/7766
Nature Genetics 1999 Apr;21(4):ppp—ppp.
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The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
N.V. Guevara, H.S. Kim, E.I. Antonova, L. Chan doi:10.1038/6585
Nature Medicine 1999 Mar;5(3):335—339.
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Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice
D. Pratic�, R.K. Tangirala, D.J. Rader, J. Rokach, G.A. FitzGerald doi:10.1038/2685
Nature Medicine 1998 Oct;4(10):1189—1192.
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Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts
L. Park, K.G. Raman, K.J. Lee, Y. Lu, L. J. Ferran, W. Sun Chow, D. Stern, A.M. Schmidt doi:10.1038/2012
Nature Medicine 1998 Sep;4(9):1025—1031.
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Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
L. Boring, J. Gosling, M. Cleary, I.F. Charo doi:10.1038/29788
Nature 1998 Aug;394(8):894—897.
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Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
DM. Shih, L Gu, YR Xia, M. Navab, W.F. Li, S. Hama, L.W. Castellani, C.E. Furlong, L.G. Costa, A.M. Fogelman, A.J. Lusis doi:10.1038/28406
Nature 1998 Jul;394(7):284—287.
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Reduction of atherosclerosis in mice by inhibition of CD40 signalling
F. Mach, U. Sch�nbeck, G.K. Sukhova, E. Atkinson, P. Libby doi:10.1038/doi
Nature 1998 Jul;394(7):200—203.
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DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
D.A. Nickerson, S.L. Taylor, K.M. Weiss, A.G. Clark, R.G. Hutchinson, J. Steng�rd, V. Salomaa, E. Vartiainen, E. Boerwinkle, C.F. Sing doi:10.1038/907
Nature Genetics 1998 Jul;19(3):233—240.
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The peroxisome proliferator-activated receptor- is a negative regulator of macrophage activation
M. Ricote, A.C. Li, T.M. Willson, C. J. Kelly, C.K. Glass doi:10.1038/34178
Nature 1998 Jan;391(1):79—82.
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