Top 10

The top ten charts the articles that have been downloaded most often, in HTML format, from the Nature Immunology website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.

1. Article

   Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

   Roman Barbalat, Laura Lau, Richard M Locksley & Gregory M Barton

   doi:10.1038/ni.1792

   Abstract - Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands | Full Text - Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands | PDF (889 KB) - Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands | Supplementary information - Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

2. Article

   Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

   Brian T Fife, Kristen E Pauken, Todd N Eagar, Takashi Obu, Jenny Wu, Qizhi Tang, Miyuki Azuma, Matthew F Krummel & Jeffrey A Bluestone

   doi:10.1038/ni.1790

   Abstract - Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal | Full Text - Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal | PDF (904 KB) - Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal | Supplementary information - Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

3. Article

   MicroRNA miR-326 regulates T_H-17 differentiation and is associated with the pathogenesis of multiple sclerosis

   Changsheng Du, Chang Liu, Jiuhong Kang, Guixian Zhao, Zhiqiang Ye, Shichao Huang, Zhenxin Li, Zhiying Wu & Gang Pei

   doi:10.1038/ni.1798

   Abstract - MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis | Full Text - MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis | PDF (1,003 KB) - MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis | Supplementary information - MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

4. Article

   Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

   Masako Murai, Olga Turovskaya, Gisen Kim, Rajat Madan, Christopher L Karp, Hilde Cheroutre & Mitchell Kronenberg

   doi:10.1038/ni.1791

   Abstract - Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis | Full Text - Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis | PDF (900 KB) - Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis | Supplementary information - Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

5. News and Views

   TLR2 joins the interferon gang

   Franz Bauernfeind & Veit Hornung

   doi:10.1038/ni1109-1139

   Full Text - TLR2 joins the interferon gang | PDF (336 KB) - TLR2 joins the interferon gang

6. Article

   An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

   Peter J R Ebert, Shan Jiang, Jianming Xie, Qi-Jing Li & Mark M Davis

   doi:10.1038/ni.1797

   Abstract - An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a | Full Text - An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a | PDF (882 KB) - An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a | Supplementary information - An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

7. Article

   An endogenous peptide positively selects and augments the activation and survival of peripheral CD4⁺ T cells

   Wan-Lin Lo, Nathan J Felix, James J Walters, Henry Rohrs, Michael L Gross & Paul M Allen

   doi:10.1038/ni.1796

   Abstract - An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells | Full Text - An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells | PDF (614 KB) - An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells | Supplementary information - An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

8. Article

   Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation

   Benjamin R Marks, Heba N Nowyhed, Jin-Young Choi, Amanda C Poholek, Jared M Odegard, Richard A Flavell & Joe Craft

   doi:10.1038/ni.1783

   Abstract - Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation | Full Text - Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation | PDF (1,185 KB) - Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation | Supplementary information - Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation

9. Article

   The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

   Teresa L M Thurston, Grigory Ryzhakov, Stuart Bloor, Natalia von Muhlinen & Felix Randow

   doi:10.1038/ni.1800

   Abstract - The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria | Full Text - The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria | PDF (940 KB) - The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria | Supplementary information - The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

10. News and Views

    Positively selecting peptides: their job does not end in the thymus

    Kai W Wucherpfennig & Etienne Gagnon

    doi:10.1038/ni1109-1143

    Full Text - Positively selecting peptides: their job does not end in the thymus | PDF (488 KB) - Positively selecting peptides: their job does not end in the thymus

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