Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationArticles
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1
production
Hendrik Poeck, Michael Bscheider, Olaf Gross, Katrin Finger, Susanne Roth, Manuele Rebsamen, Nicole Hannesschläger, Martin Schlee, Simon Rothenfusser, Winfried Barchet, Hiroki Kato, Shizuo Akira, Satoshi Inoue, Stefan Endres, Christian Peschel, Gunther Hartmann, Veit Hornung & Jürgen Ruland
Published online: 15 November 2009 | doi:10.1038/ni.1824
Production of mature interleukin 1
(IL-1) requires Il1b transcription and inflammasome-mediated processing of IL-1 protein. Ruland and colleagues show that the RNA virus sensor RIG-I signals via the adaptors CARD9 and Asc to facilitate both processes.
Abstract - | Full Text - Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 production | PDF (765 KB) - Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 production |
Supplementary information
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Leonardo H Travassos, Leticia A M Carneiro, Mahendrasingh Ramjeet, Seamus Hussey, Yun-Gi Kim, João G Magalhães, Linda Yuan, Fraser Soares, Evelyn Chea, Lionel Le Bourhis, Ivo G Boneca, Abdelmounaaim Allaoui, Nicola L Jones, Gabriel Nuñez, Stephen E Girardin & Dana J Philpott
Published online: 08 November 2009 | doi:10.1038/ni.1823
Autophagy facilitates host defense against invading bacteria. Philpott and colleagues show that Nod1 and Nod2 link pathogen sensing to autophagy by recruiting the autophagy protein AGT16L1 to the site of pathogen entry.
Abstract - | Full Text - Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry | PDF (1,147 KB) - Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry | Supplementary information
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A A Vignali & Michael Karin
Published online: 08 November 2009 | doi:10.1038/ni.1819
TLR4 signals via MyD88 and TRIF to activate proinflammatory cytokine and type I interferon responses. Karin and colleagues show that different ubiquitination of TRAF3 via K48 or K63 dictates the ensuing immune response.
Abstract - | Full Text - Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines | PDF (1,415 KB) - Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines | Supplementary information
Enteric defensins are essential regulators of intestinal microbial ecology
Nita H Salzman, Kuiechun Hung, Dipica Haribhai, Hiutung Chu, Jenny Karlsson-Sjöberg, Elad Amir, Paul Teggatz, Melissa Barman, Michael Hayward, Daniel Eastwood, Maaike Stoel, Yanjiao Zhou, Erica Sodergren, George M Weinstock, Charles L Bevins, Calvin B Williams & Nicolaas A Bos
Published online: 22 October 2009 | doi:10.1038/ni.1825
Defensins combat pathogenic bacteria invading the mammalian intestine. Salzman and co-workers find that defensins influence the composition of the small intestinal commensal microbiota and the presence of interleukin 17–producing T cells in the lamina propria.
Abstract - | Full Text - Enteric defensins are essential regulators of intestinal microbial ecology | PDF (923 KB) - Enteric defensins are essential regulators of intestinal microbial ecology | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Immunology advance online publication, day month year (doi:10.1038/niXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Immunology volume, page (year); advance online publication, (doi:10.1038/niXXXXX)".
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