Focus on Leukocyte Trafficking

On the move - p947

doi:10.1038/ni0908-947

Leukocytes express an array of chemoattractant and adhesion receptors that govern their migration, behavior and survival.

Full Text - On the move | PDF (218 KB) - On the move

Focus on Leukocyte Trafficking

Chemokines and leukocyte traffic - pp949 - 952

Federica Sallusto & Marco Baggiolini

doi:10.1038/ni.f.214

Abstract - | Full Text - Chemokines and leukocyte traffic | PDF (532 KB) - Chemokines and leukocyte traffic

Focus on Leukocyte Trafficking

How chemokines invite leukocytes to dance - pp953 - 959

Marcus Thelen & Jens V Stein

doi:10.1038/ni.f.207

Abstract - | Full Text - How chemokines invite leukocytes to dance | PDF (558 KB) - How chemokines invite leukocytes to dance | Supplementary information

Focus on Leukocyte Trafficking

Interstitial leukocyte migration and immune function - pp960 - 969

Peter Friedl & Bettina Weigelin

doi:10.1038/ni.f.212

Abstract - | Full Text - Interstitial leukocyte migration and immune function | PDF (2,260 KB) - Interstitial leukocyte migration and immune function | Supplementary information

Focus on Leukocyte Trafficking

Orchestrating the orchestrators: chemokines in control of T cell traffic - pp970 - 980

Shannon K Bromley, Thorsten R Mempel & Andrew D Luster

doi:10.1038/ni.f.213

Abstract - | Full Text - Orchestrating the orchestrators: chemokines in control of T cell traffic | PDF (4,018 KB) - Orchestrating the orchestrators: chemokines in control of T cell traffic

Focus on Leukocyte Trafficking

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking - pp981 - 987

Hekla Sigmundsdottir & Eugene C Butcher

doi:10.1038/ni.f.208

Abstract - | Full Text - Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking | PDF (2,034 KB) - Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

Focus on Leukocyte Trafficking

Moving targets: cell migration inhibitors as new anti-inflammatory therapies - pp988 - 998

Charles R Mackay

doi:10.1038/ni.f.210

Abstract - | Full Text - Moving targets: cell migration inhibitors as new anti-inflammatory therapies | PDF (1,156 KB) - Moving targets: cell migration inhibitors as new anti-inflammatory therapies

Focus on Leukocyte Trafficking

Research Highlights - p999

doi:10.1038/ni0908-999

Full Text - Research Highlights | PDF (118 KB) - Research Highlights

Tolerance can be infectious - pp1001 - 1003

Herman Waldmann

doi:10.1038/ni0908-1001

Abstract - | Full Text - Tolerance can be infectious | PDF (238 KB) - Tolerance can be infectious

Building networks for immunodeficiency diseases and immunology training - pp1005 - 1007

Peter D Burrows & Alain Fischer

doi:10.1038/ni0908-1005

Abstract - | Full Text - Building networks for immunodeficiency diseases and immunology training | PDF (472 KB) - Building networks for immunodeficiency diseases and immunology training

The making of NKT cells - pp1009 - 1011

Laurent Gapin

doi:10.1038/ni0908-1009

Natural killer T cells acquire their unique phenotype and characteristics during development in the thymus. Evidence suggests that the transcription factor PLZF has a unique function in the development of these cells and their acquisition of 'innate-like' characteristics.

Full Text - The making of NKT cells | PDF (543 KB) - The making of NKT cells

See also: Article by Kovalovsky et al.

The CD200-CD200R axis in local control of lung inflammation - pp1011 - 1013

Patrick G Holt & Deborah H Strickland

doi:10.1038/ni0908-1011

Excessive lung inflammation in response to infection or allergens can lead to tissue damage and potentially loss of organ function. The CD200-CD200R interaction acts to limit such destructive immune responses in the lung.

Full Text - The CD200-CD200R axis in local control of lung inflammation | PDF (548 KB) - The CD200-CD200R axis in local control of lung inflammation

See also: Article by Snelgrove et al.

Regulation of NKG2D ligands: a purposeful but delicate affair - pp1013 - 1015

Thomas Spies

doi:10.1038/ni0908-1013

New findings show that cellular microRNAs 'calibrate' the baseline expression of mRNAs encoding stress-inducible ligands of the activating NKG2D receptor. This regulation serves to protect innocent cells but may be exploited by tumors and viruses to thwart immune attack.

Full Text - Regulation of NKG2D ligands: a purposeful but delicate affair | PDF (520 KB) - Regulation of NKG2D ligands: a purposeful but delicate affair

See also: Article by Stern-Ginossar et al.

A birthday gift for TRADD - pp1015 - 1016

Gioacchino Natoli & Liv M I Austenaa

doi:10.1038/ni0908-1015

Definitive new data solidify and clarify the function of the adaptor TRADD in tumor necrosis factor receptor 1 signaling and show that in some situations, TRADD is also required for the transmission of Toll-like receptor signals.

Full Text - A birthday gift for TRADD | PDF (1,772 KB) - A birthday gift for TRADD

See also: Article by Ermolaeva et al. | Article by Pobezinskaya et al.

Research Highlights - p1017

doi:10.1038/ni0908-1017

Full Text - Research Highlights | PDF (117 KB) - Research Highlights

The kinase p38 serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression - pp1019 - 1027

Chun Kim, Yasuyo Sano, Kristina Todorova, Bradley A Carlson, Luis Arpa, Antonio Celada, Toby Lawrence, Kinya Otsu, Janice L Brissette, J Simon C Arthur & Jin Mo Park

doi:10.1038/ni.1640

The function of the kinase p38 in inflammation is unclear. Park and colleagues show that p38 exerts pro- or anti-inflammatory effects depending on the cell type in which it is expressed and the stimulus eliciting its activation.

Abstract - | Full Text - The kinase p38 serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression | PDF (794 KB) - The kinase p38 serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression | Supplementary information

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling - pp1028 - 1036

Olga Ananieva, Joanne Darragh, Claus Johansen, Julia M Carr, Joanne McIlrath, Jin Mo Park, Andrew Wingate, Claire E Monk, Rachel Toth, Susana G Santos, Lars Iversen & J Simon C Arthur

doi:10.1038/ni.1644

Uncontrolled TLR signaling results in excessive inflammation. Arthur and colleagues show that the kinases MSK1 and MSK2 orchestrate a feedback loop involving interleukin 10 and the phosphatase DUSP1 to control TLR4 signaling.

Abstract - | Full Text - The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling | PDF (585 KB) - The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling | Supplementary information

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses - pp1037 - 1046

Maria A Ermolaeva, Marie-Cécile Michallet, Nikoletta Papadopoulou, Olaf Utermöhlen, Ksanthi Kranidioti, George Kollias, Jürg Tschopp & Manolis Pasparakis

doi:10.1038/ni.1638

The function of the adaptor protein TRADD is uncertain. Teams led by Pasparakis and Liu solidify TRADD's function in TNF receptor signaling and extend its influence to TRIF-dependent Toll-like receptor pathways.

Abstract - | Full Text - Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses | PDF (633 KB) - Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses | Supplementary information

See also: News and Views by Natoli & Austenaa | Article by Pobezinskaya et al.

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors - pp1047 - 1054

Yelena L Pobezinskaya, You-Sun Kim, Swati Choksi, Michael J Morgan, Tao Li, Chengyu Liu & Zhenggang Liu

doi:10.1038/ni.1639

The function of the adaptor protein TRADD is uncertain. Teams led by Pasparakis and Liu solidify TRADD's function in TNF receptor signaling and extend its influence to TRIF-dependent Toll-like receptor pathways.

Abstract - | Full Text - The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors | PDF (549 KB) - The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors | Supplementary information

See also: News and Views by Natoli & Austenaa | Article by Ermolaeva et al.

The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions - pp1055 - 1064

Damian Kovalovsky, Olisambu U Uche, Sonia Eladad, Robin M Hobbs, Woelsung Yi, Eric Alonzo, Kevin Chua, Maggie Eidson, Hye-Jung Kim, Jin S Im, Pier Paolo Pandolfi & Derek B Sant'Angelo

doi:10.1038/ni.1641

Invariant natural killer cells recognize glycolipids presented by CD1d molecules and can mediate rapid innate responses. Sant'Angelo and colleagues show that these cells express the transcription factor PLZF, which is required for their innate effector function.

Abstract - | Full Text - The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions | PDF (1,024 KB) - The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions | Supplementary information

See also: News and Views by Gapin

Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D - pp1065 - 1073

Noam Stern-Ginossar, Chamutal Gur, Moshe Biton, Elad Horwitz, Moran Elboim, Noa Stanietsky, Michal Mandelboim & Ofer Mandelboim

doi:10.1038/ni.1642

The mechanisms controlling expression of the stress-induced NKG2D ligands MICA and MICB are not fully understood. Mandelboim and colleagues suggest that microRNAs maintain low MICA and MICB expression in the absence of cell stress.

Abstract - | Full Text - Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D | PDF (643 KB) - Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D | Supplementary information

See also: News and Views by Spies

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection - pp1074 - 1083

Robert J Snelgrove, John Goulding, Arnaud M Didierlaurent, Daphne Lyonga, Seema Vekaria, Lorna Edwards, Emily Gwyer, Jonathon D Sedgwick, A Neil Barclay & Tracy Hussell

doi:10.1038/ni.1637

Lungs are continually challenged by exposure to airborne particles and microbes, yet they resist overt inflammatory responses. Hussell and colleagues show that this 'quiescent' state requires CD200-CD200R interactions between alveolar macrophages and lung tissues.

Abstract - | Full Text - A critical function for CD200 in lung immune homeostasis and the severity of influenza infection | PDF (633 KB) - A critical function for CD200 in lung immune homeostasis and the severity of influenza infection | Supplementary information

See also: News and Views by Holt & Strickland