Table 2
From the following article
Moving targets: cell migration inhibitors as new anti-inflammatory therapies
Charles R Mackay
Nature Immunology 9, 988 - 998 (2008) Published online: 19 August 2008
doi:10.1038/ni.f.210
Table 2. Some important polymorphisms in human cell migration–related systems, and inflammatory disease associations
| Gene | Polymorphism, location | Effect on protein expression | Association with disease | Ref. |
|---|---|---|---|---|
| CCR5 |  32,
coding region | Absence of CCR5 on leukocytes |  rheumatoid arthritis
transplant rejection | 34, 35, 36 |
| CX3CR1 | V249I/ T280M | CX3CR1 | coronary artery disease
age-related macular degeneration | 90 |
| CCR2 | Val64Ile | CCR2 | acute transplant rejection
coronary artery disease | 91,92 |
| CCL26 | Promoter |  CCL26 | eosinophilic esophagitis | 44 |
| CFH (Complement factor H) | Coding region
Y402H | complement pathway activation | age-related macular degeneration
autoimmune kidney diseases | 15 |
| CCL2 | -2518,
promoter | CCL2 | bronchial asthma
allograft rejection
Crohn's disease
psoriasis | 93 |
| GPR44 (CrTh2) | 3' UTR | mRNA stability | asthma incidence and severity | 94 |
