News and Views
Nature Immunology 9, 1013 - 1015 (2008)
doi:10.1038/ni0908-1013
Regulation of NKG2D ligands: a purposeful but delicate affair
Thomas Spies1
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Thomas Spies is with the Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
e-mail: tspies@fhcrc.org
Abstract
New findings show that cellular microRNAs 'calibrate' the baseline expression of mRNAs encoding stress-inducible ligands of the activating NKG2D receptor. This regulation serves to protect innocent cells but may be exploited by tumors and viruses to thwart immune attack.
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