Review abstract
Nature Immunology 9, 970 - 980 (2008)
Published online: 19 August 2008 | doi:10.1038/ni.f.213
Orchestrating the orchestrators: chemokines in control of T cell traffic
Shannon K Bromley1,2, Thorsten R Mempel1,2 & Andrew D Luster1
Abstract
The understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably. So far, over 50 chemokines and 20 chemokine receptors have been identified. Detailed analyses have demonstrated the function of chemokine receptors on T cell subsets, the temporal and spatial expression patterns of chemokines in vivo and the phenotypes of animals genetically deficient in one component or several components of the chemokine-chemokine receptor system. New microscopy modalities for studying the influence of chemokines on the migratory activity of T cells in the lymph node have also brought new insights. Here we review such advances with particular emphasis on control of the migration of T cell subsets in lymph nodes and in peripheral tissues in homeostasis and inflammation.
- Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
- These authors contributed equally to this work.
Correspondence to: Andrew D Luster1 e-mail: aluster@mgh.harvard.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Armed and ready: How effector T cells deploy in reactive lymph nodes to modulate immunityNature Immunology News and Views (01 Jul 2007)
A new player in lymphocyte homingNature Immunology News and Views (01 Apr 2008)
See all 8 matches for News And ViewsRESEARCH
Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organsNature Immunology Article (01 May 2007)
See all 38 matches for Research
