Review abstract
Nature Immunology 9, 953 - 959 (2008)
Published online: 19 August 2008 | doi:10.1038/ni.f.207
How chemokines invite leukocytes to dance
Marcus Thelen1 & Jens V Stein2
Abstract
A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor–induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases.
- Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.
- Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH-3012 Bern, Switzerland.
Correspondence to: Marcus Thelen1 e-mail: marcus.thelen@irb.unisi.ch
Correspondence to: Jens V Stein2 e-mail: jens.stein@tki.unibe.ch
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