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Nature Immunology 9, 833–834 (1 August 2008) | doi:10.1038/ni0808-833
Distinct functions for HS1 in chemosensory versus adhesive signaling
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Abstract
Many lymphocytes must balance continuous host surveillance through motility, with adhesion and target cell recognition mediated by the activation of immune receptors. Lymphocytes, such as natural killer (NK) cells in search of virus-infected target cells and T cells seeking antigen-presenting cells bearing agonist peptides, must coordinate signaling pathways that allow movement toward target cells with pathways that induce the arrest and killing of target cells or activation of effector lymphocytes.
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