News and Views
Nature Immunology 9, 833 - 834 (2008)
doi:10.1038/ni0808-833
Distinct functions for HS1 in chemosensory versus adhesive signaling
Peter Beemiller1 & Matthew F Krummel1
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Peter Beemiller and Matthew F. Krummel are in the Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA.
e-mail: matthew.krummel@ucsf.edu
Abstract
Host immunity requires cytotoxic lymphocytes that are able to move toward their targets but are also able to stop after identifying target cells and then establish stable cell-cell contact. A new study shows that separate phosphorylation sites in HS1, an actin cytoskeleton–remodeling factor, can regulate both processes.
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