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Nature Immunology 9, 831 - 833 (2008)
doi:10.1038/ni0808-831
NLRs and the dangers of pollution and aging
Stephen B Willingham1 & Jenny P-Y Ting2
- Stephen B. Willingham is with the Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA.
-
Jenny P.-Y. Ting is in the Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
e-mail: panyun@med.unc.edu
Abstract
The production of inflammatory interleukin 1
after uptake of silica crystals and alum salt or amyloid- occurs by a process that involves lysosomal destabilization and release of cathepsin B that activates the NLRP3 inflammasome.
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RESEARCH
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationNature Immunology Article (01 Aug 2008)
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