Article abstract

Nature Immunology 9, 908 - 916 (2008)
Published online: 6 July 2008 | doi:10.1038/ni.1634

Autophagic control of listeria through intracellular innate immune recognition in drosophila

Tamaki Yano1, Shizuka Mita1, Hiroko Ohmori2, Yoshiteru Oshima1, Yukari Fujimoto3, Ryu Ueda4, Haruhiko Takada5, William E Goldman6, Koichi Fukase3, Neal Silverman7, Tamotsu Yoshimori2 & Shoichiro Kurata1

Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic components, has been linked to the elimination of intracellular pathogens during mammalian innate immune responses. However, the mechanisms underlying cytoplasmic infection-induced autophagy and the function of autophagy in host survival after infection with intracellular pathogens remain unknown. Here we report that in drosophila, recognition of diaminopimelic acid–type peptidoglycan by the pattern-recognition receptor PGRP-LE was crucial for the induction of autophagy and that autophagy prevented the intracellular growth of Listeria monocytogenes and promoted host survival after this infection. Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense.

  1. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
  2. Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 103-0027, Japan.
  3. Graduate School of Science, Osaka University, Osaka 560-0043, Japan.
  4. National Institute of Genetics, Mishima 411-8540, Japan.
  5. Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
  6. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  7. Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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