Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
News and Views
Nature Immunology 9, 718–720 (1 July 2008) | doi:10.1038/ni0708-718
Nuclear geography and allelic exclusion
Abstract
During lymphoid development, variable (V), diversity (D), and joining (J) gene elements are assembled by somatic DNA recombination to generate antigen receptors. V(D)J gene rearrangement is initiated by binding of the recombination-activating gene products RAG-1 and RAG-2 to the recombination signal sequences that flank the V, D and J elements.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
