News and Views


Nature Immunology 9, 718 - 720 (2008)
doi:10.1038/ni0708-718

Nuclear geography and allelic exclusion

Cornelis Murre1

  1. Cornelis Murre is in the Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.
    e-mail: murre@biomail.ucsd.edu


The mechanisms responsible for establishing allelic exclusion remain enigmatic. New data indicate that stochastic interactions of antigen-receptor alleles with repressive nuclear compartments may contribute to the mechanisms that support allelic exclusion.

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