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Nature Immunology 9, 716 - 718 (2008)
Corrected online: 21 July 2008 | doi:10.1038/ni0708-716

PTEN gives neutrophils direction

Daniel D Billadeau1

  1. Daniel D. Billadeau is in the Department of Immunology and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
    e-mail: billadeau.daniel@mayo.edu


Neutrophils can respond to many chemotactic signals, but how these cells 'prioritize' such signals to react to invading pathogens has remained unclear. The phosphatase PTEN seems to be critical in directing the migration of neutrophils toward their end target in a complex milieu of competing signals.

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* In the version of this article initially published, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) is incorrectly identified as phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2). The error has been corrected in the HTML and PDF versions of the article.

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